ArticleThe Journal of cell biology1983
Three-dimensional structure of actin filaments and of an actin gel made with actin-binding protein.
Article in The Journal of cell biology, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 119 citations in OpenAlex.
- Myosin-5a facilitates stress granule formation by interacting with G3BP1.Cellular and molecular life sciences : CMLS · 2024Article
- A Stop-gain Variant c.220C>T (p.(Gln74*)) inThe Yale journal of biology and medicine · 2023Review
- Materials science and mechanosensitivity of living matter.Applied physics reviews · 2022Review
- Isoform-specific roles of the Drosophila filamin-type protein Jitterbug (Jbug) during development.Genetics · 2021Article
- The mechanobiome: a goldmine for cancer therapeutics.American journal of physiology. Cell physiology · 2021Review
- Cytoplasmic transport and nuclear import of plasmid DNA.Bioscience reports · 2017Review
- Structural basis of filamin A functions.The Journal of cell biology · 2007Article
- Intracellular trafficking of plasmids for gene therapy: mechanisms of cytoplasmic movement and nuclear import.Current gene therapy · 2006Review
- Filamin-a and rheological properties of cultured melanoma cells.Biophysical journal · 2006Article
- Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells.The Journal of cell biology · 2001Article
- Filamin is required for ring canal assembly and actin organization during Drosophila oogenesis.The Journal of cell biology · 1999Article
- Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation.The Journal of cell biology · 1999Article
- Interaction of presenilins with the filamin family of actin-binding proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Tracer diffusion through F-actin: effect of filament length and cross-linking.Biophysical journal · 1996Article
- Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods.The Journal of cell biology · 1995Article
- Affinity of alpha-actinin for actin determines the structure and mechanical properties of actin filament gels.Biophysical journal · 1993Article
- A 27,000-D core of the Dictyostelium 34,000-D protein retains Ca(2+)-regulated actin cross-linking but lacks bundling activity.The Journal of cell biology · 1993Article
- Targeted disruption of the ABP-120 gene leads to cells with altered motility.The Journal of cell biology · 1992Article
- Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.The Journal of cell biology · 1990Article
- Brownian motion of inert tracer macromolecules in polymerized and spontaneously bundled mixtures of actin and filamin.The Journal of cell biology · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Purified muscle actin and mixtures of actin and actin-binding protein were examined in the transmission electron microscope after fixation, critical point drying, and rotary shadowing. The three-dimensional structure of the protein assemblies was analyzed by a computer-assisted graphic analysis applicable to generalized filament networks. This analysis yielded information concerning the frequency of filament intersections, the filament length between these intersections, the angle at which filaments branch at these intersections, and the concentration of filaments within a defined volume. Purified actin at a concentration of 1 mg/ml assembled into a uniform mass of long filaments which overlap at random angles between 0 degrees and 90 degrees. Actin in the presence of macrophage actin-binding protein assembled into short, straight filaments, organized in a perpendicular branching network. The distance between branch points was inversely related to the molar ratio of actin-binding protein to actin. This distance was what would be predicted if actin filaments grew at right angles off of nucleation sites on the two ends of actin-binding protein dimers, and then annealed. The results suggest that actin in combination with actin-binding protein self-assembles to form a three-dimensional network resembling the peripheral cytoskeleton of motile cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.