ArticleAnatomy and embryology1983
The embryonic development of the cerebellum in normal and reeler mutant mice.
Article in Anatomy and embryology, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 147 citations in OpenAlex.
- Purkinje cell arrival at the Purkinje cell layer orchestrates cerebellar foliation and its temporal sequence.iScience · 2026Article
- Maternal Infection Impairs Motor Coordination in an Experimental Meningitis Rat Model Through Altered MMP-2/3/9 Activity, H3K4 Trimethylation, andInternational journal of molecular sciences · 2026Article
- Cerebellar structure and function abnormalities in 16p11.2 microduplication mice.Brain communications · 2026Article
- Developmental transformations of Purkinje cells tracked by DNA electrokinetic mobility.Cell reports methods · 2025Article
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias.bioRxiv : the preprint server for biology · 2023Article
- White matter abnormalities in fetal alcohol spectrum disorders: Focus on axon growth and guidance.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Article
- A Focus on the Cerebellum: From Embryogenesis to an Age-Related Clinical Perspective.Frontiers in systems neuroscience · 2021Review
- Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation.Biomolecules · 2020Review
- Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions.International journal of molecular sciences · 2020Review
- Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?Cerebellum (London, England) · 2019Review
- Reelin Signaling Controls the Preference for Social Novelty in Zebrafish.Frontiers in behavioral neuroscience · 2019Article
- Neuronal Migration During Development of the Cerebellum.Frontiers in cellular neuroscience · 2018Review
- GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function.Cell reports · 2017Article
- Consensus Paper: Cerebellar Development.Cerebellum (London, England) · 2016Review
- New Insights into Reelin-Mediated Signaling Pathways.Frontiers in cellular neuroscience · 2016Review
- Maternal immune activation produces cerebellar hyperplasia and alterations in motor and social behaviors in male and female mice.Cerebellum (London, England) · 2015Article
- Reelin supplementation recovers synaptic plasticity and cognitive deficits in a mouse model for Angelman syndrome.The European journal of neuroscience · 2015Article
- From mice to men: lessons from mutant ataxic mice.Cerebellum & ataxias · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of the cerebellum has been studied in normal and reeler mice, from embryonic day fourteen, i.e. when morphogenesis begins in this organ, to birth. The cerebellar nuclei develop according to a similar sequence in both genotypes. Their neurons migrate into the rostral field of the cerebellar bud where they condense in a rounded mass, well defined at E14. From E17, this cell contingent spreads transversally and the three roof nuclei become clearly defined. In reeler mutants, there seems to be an abnormal development of the architectonics of the lateral nucleus. The Purkinje cells migrate into the cortex at the same time in both genotypes. In the normal animal, from E14 onward, Purkinje cells are condensed in a clearly defined plate, where they assume a radial organization. By contrast, the mutant Purkinje cells are not arranged in a plate but are scattered in the periphery of the cortex. The neurons of the external granular layer are identical in both genotypes. Radial glial fibers and early Golgi epithelial cells appear to be normally present in the reeler embryo. The foliation of the cerebellar cortex begins at E17 in the normal embryo. From this stage onward, foliation is increasingly deficient in reeler mutants. Based on these observations, it is suggested that, in normal cerebellar development, a specific, genetically determined mechanism is responsible for the organization and the stabilization of postmigratory neurons and that this mechanism is affected by the reeler mutation.
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