ArticleMolecular and cellular biology1983
Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.
Article in Molecular and cellular biology, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 384 citations in OpenAlex.
- Insights on Droplet Digital PCR-Based Cellular Kinetics and Biodistribution Assay Support for CAR-T Cell Therapy.The AAPS journal · 2021Article
- Accurate measurement of mitochondrial DNA deletion level and copy number differences in human skeletal muscle.PloS one · 2014Article
- Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels.PloS one · 2013Article
- Plant vegetative and animal cytoplasmic actins share functional competence for spatial development with protists.The Plant cell · 2012Article
- Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia.Molecular biology of the cell · 2002Article
- Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements.Molecular biology of the cell · 1999Article
- Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair.The American journal of pathology · 1999Article
- Endogenous production of tumour necrosis factor is required for manganese superoxide dismutase expression by irradiation in the human monocytic cell line THP-1.The Biochemical journal · 1997Article
- Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The anti-cancer agent distamycin A displaces essential transcription factors and selectively inhibits myogenic differentiation.Molecular and cellular biochemistry · 1997Article
- A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblasts.The Journal of cell biology · 1996Article
- Expression of extracellular matrix proteoglycans perlecan and decorin in carbon-tetrachloride-injured rat liver and in isolated liver cells.The American journal of pathology · 1996Article
- Dietary marine lipids suppress continuous expression of interleukin-1 beta gene transcription.Lipids · 1996Article
- The specific NH2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo.The Journal of cell biology · 1995Article
- Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.British journal of cancer · 1995Article
- The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Sequences responsible for intracellular localization of beta-actin messenger RNA also affect cell phenotype.The Journal of cell biology · 1994Article
- All histological types of primary human rhabdomyosarcoma express alpha-cardiac and not alpha-skeletal actin messenger RNA.The American journal of pathology · 1994Article
- Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death.The Journal of clinical investigation · 1994Article
- Multiple levels of control of the stage- and region-specific expression of rat intestinal lactase.The Journal of cell biology · 1993Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have constructed isotype-specific subclones from the 3' untranslated regions of alpha-skeletal, alpha-cardiac, beta-cytoskeletal, and gamma-cytoskeletal actin cDNAs. These clones have been used as hybridization probes to assay the number and organization of these actin isotypes in the human genome. Hybridization of these probes to human genomic actin clones (Engel et al., Proc. Natl. Acad. Sci. U.S.A. 78:4674-4678, 1981; Engel et al., Mol. Cell. Biol. 2:674-684, 1982) has allowed the unambiguous assignment of the genomic clones to isotypically defined actin subfamilies. In addition, only one isotype-specific probe hybridizes to each actin-containing gene, with a single exception. This result suggests that the multiple actin genes in the human genome are not closely linked. Genomic DNA blots probed with these subclones under stringent conditions demonstrate that the alpha-skeletal and alpha-cardiac muscle actin genes are single copy, whereas the cytoskeletal actins, beta and gamma, are present in multiple copies in the human genome. Most of the actin genes of other mammals are cytoplasmic as well. These observations have important implications for the evolution of multigene families.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.