ArticleProceedings of the National Academy of Sciences of the United States of America1983
Age-associated impairment of murine natural killer activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 74 citations in OpenAlex.
- Environmental Enrichment Exposure Alleviates Geriatric Depressive-Like Symptoms through Regulating Neurogenesis and Neuroinflammation.Environment & health (Washington, D.C.) · 2025Article
- MARS: discovering novel cell types across heterogeneous single-cell experiments.Nature methods · 2020Article
- The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment.Aging cell · 2015Article
- The host environment is responsible for aging-related functional NK cell deficiency.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models.Aging and disease · 2011Article
- Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer.BMC immunology · 2010Article
- Susceptibility of the aging lung to environmental injury.Seminars in respiratory and critical care medicine · 2010Review
- The aging immune system and its relationship to the development of chronic obstructive pulmonary disease.Proceedings of the American Thoracic Society · 2009Review
- NK and NKT cells in aging and longevity: role of zinc and metallothioneins.Journal of clinical immunology · 2009Review
- Innate immunity and aging.Experimental gerontology · 2008Review
- Echinacea: a miracle herb against aging and cancer? Evidence in vivo in mice.Evidence-based complementary and alternative medicine : eCAM · 2005Article
- Skin tumors in aging Long Evans rats.Journal of the National Medical Association · 2002Article
- Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease.The Journal of clinical investigation · 2002Article
- Opposing influence of age on the growth and colony-forming ability of mouse melanoma B16 and mammary adenocarcinoma: correlation with natural killer activity.Cancer immunology, immunotherapy : CII · 1990Article
- Lack of a relationship between immune function and chemically induced hepatocarcinogenesis in B6C3F1 mice.Cancer immunology, immunotherapy : CII · 1988Article
- Suppression of natural killer-cell function in humans following thermal and traumatic injury.Journal of clinical immunology · 1986Article
- Murine natural resistance to Trypanosoma lewisi involves complement component C3 and radiation-resistant, silica dust-sensitive effector cells.Infection and immunity · 1985Article
- Interaction between murine natural killer cells and trypanosomes of different species.Infection and immunity · 1984Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Natural cell-mediated cytotoxicity may be critical in the resistance displayed by animals and humans to tumors and various pathogenic microorganisms. Because the frequency of tumors and infections increases markedly in aging populations, we have compared the natural killer (NK) competence of lymphoid tissues (spleen, bone marrow) and of peritoneal cells of young adult and aged mice. Spontaneous NK activity was much lower, and the rate of target cell lysis was much less, in aged mice. The level of NK activity was only modestly increased in old, compared to young, mice when they were exposed to Trypanosoma musculi, an organism that provides strong stimulation of NK activity. Restricted NK activity of aged mice was not attributable to suppressor cells. The NK effector cells in old mice were characterized as being nonadherent to plastic, completely susceptible to lysis by complement plus an antiserum against specificity NK 1.2, and only slightly affected by treatment with antiserum against specificity Thy-1.2. Two indirect methods were employed to assess the relative frequency of splenic NK cells at the time of maximal stimulation by T. musculi: a cytotoxicity assay with antiserum against NK 1.2 and a binding assay involving monolayers of YAC-1 tumor target cells. Similar results were obtained in both assays, indicating that at maximal stimulation about 10% of the total spleen cells of both young and old mice were NK cells. We conclude (cautiously) that the functional efficiency of aged NK cells is impaired and that this defect may account, in part, for reduced ability of aged individuals to resist certain types of cancer and certain pathogenic microorganisms.
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Registered trials
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