ArticleProceedings of the National Academy of Sciences of the United States of America1984
Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed, 326 citations in OpenAlex.
- Transcriptomics, Proteomics and Bioinformatics in Atrial Fibrillation: A Descriptive Review.Bioengineering (Basel, Switzerland) · 2025Review
- Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain.Scientific reports · 2024Article
- Identification and functional analysis of variants of MYH6 gene promoter in isolated ventricular septal defects.BMC medical genomics · 2022Article
- Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo.Communications biology · 2022Article
- Electrical stimulation induces differentiation of human cardiosphere-derived cells (hCDCs) to committed cardiomyocyte.Molecular and cellular biochemistry · 2020Article
- Sex-Based Mhrt Methylation Chromatinizes MeCP2 in the Heart.iScience · 2019Article
- Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals.Comprehensive physiology · 2019Review
- Muscle Contraction.Cold Spring Harbor perspectives in biology · 2018Review
- Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats.Scientific reports · 2017Article
- Genome-wide analysis of alternative splicing during human heart development.Scientific reports · 2016Article
- Activation of Foxo1 by insulin resistance promotes cardiac dysfunction and β-myosin heavy chain gene expression.Circulation. Heart failure · 2015Article
- Interplay of chromatin modifications and non-coding RNAs in the heart.Epigenetics · 2014Review
- Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells.Science and technology of advanced materials · 2013Article
- Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene.BMC evolutionary biology · 2013Article
- Remarkable heterogeneity in myosin heavy-chain composition of the human young masseter compared with young biceps brachii.Histochemistry and cell biology · 2012Article
- Interspecific and intragenic differences in codon usage bias among vertebrate myosin heavy-chain genes.Journal of molecular evolution · 2011Article
- Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.The Journal of clinical investigation · 2011Article
- A rare variant in MYH6 is associated with high risk of sick sinus syndrome.Nature genetics · 2011Article
- Cardiac myosin heavy chain gene regulation by thyroid hormone involves altered histone modifications.American journal of physiology. Heart and circulatory physiology · 2010Article
- Several common variants modulate heart rate, PR interval and QRS duration.Nature genetics · 2010Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two ventricular myosin heavy chains (MHCs), alpha and beta, which exhibit different levels of ATPase activity, are differentially expressed during development, in response to thyroid hormone and in several pathological conditions. We have isolated and analyzed the structure of the genes coding for alpha- and beta-MHC mRNAs in the rat. Detailed analysis of eight overlapping MHC genomic clones shows that the alpha- and beta-MHC genes are organized in tandem and span 50 kilobases of the chromosome. The beta-MHC gene, predominantly expressed in late fetal life, is located 4 kilobases upstream from the alpha-MHC gene, predominantly expressed in the adult. These two genes are very closely related at the nucleotide sequence level, suggesting that they have arisen by duplication of a common ancestor, yet their expression in the ventricular myocardium has been shown to be regulated in an antithetic fashion by thyroid hormone.
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