ArticleProceedings of the National Academy of Sciences of the United States of America1984
Membrane proteins unique to vertebrate olfactory cilia: candidates for sensory receptor molecules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 79 citations in OpenAlex.
- Nasal saline irrigation has no effect on normal olfaction: a prospective randomized trial.International forum of allergy & rhinology · 2014Trial
- SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways.JCI insight · 2022Article
- Protein kinase C sensitizes olfactory adenylate cyclase.The Journal of general physiology · 1993Article
- Membrane fluidity changes of liposomes in response to various odorants. Complexity of membrane composition and variety of adsorption sites for odorants.Biophysical journal · 1990Article
- "Bundle blot" purification and initial protein characterization of hair cell stereocilia.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Isolation and characterization of an olfactory mutant in Drosophila with a chemically specific defect.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Principles of odor coding and a neural network for odor discrimination.Biophysical journal · 1988Article
- Triton-labile antigens in flagella isolated from Giardia lamblia.Parasitology research · 1988Article
- Olfaction by melanophores: what does it mean?Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- The effect of concanavalin A on the rat electro-olfactogram. Differential inhibition of odorant response.The Biochemical journal · 1987Article
- Olfactory GTP-binding protein: signal-transducing polypeptide of vertebrate chemosensory neurons.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Bacterial chemotaxis and vertebrate olfaction.Experientia · 1986Review
- Isolation and characterization of an olfactory receptor protein for odorant pyrazines.Proceedings of the National Academy of Sciences of the United States of America · 1985Article
- Evidence for a tubulin-containing lipid-protein structural complex in ciliary membranes.The Journal of cell biology · 1985Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In search for olfactory receptor molecules, we carried out comprehensive electrophoretic mapping of membrane proteins in the cilia of frog olfactory epithelium. Seven polypeptides, extracted from isolated cilia by nonionic detergent, were unique to the sensory organelles, compared to nonsensory (respiratory) counterparts. Olfactory cilia contained 3-10 times more membrane-associated protein as compared to respiratory cilia, in agreement with reported densities of freeze-fracture intramembranous particles. Four of the olfactory polypeptides were major constituents of the ciliary membrane, each amounting to greater than 10% of its total protein. Three major and one minor specific polypeptide were glycosylated, whereas membranes of nonsensory cilia were practically devoid of glycoproteins. A clear difference in surface composition was also shown by microscopic visualization of fluoresceinated lectin bound to intact isolated cilia. Two of the olfactory glycoproteins displayed pronounced heterogeneity of apparent molecular weight, which could partly be due to protein sequence diversity, as expected for odorant receptor molecules. The recently described inhibition of odorant-evoked sensory potentials by the lectin concanavalin A is consistent with the hypothesis that one or more of the specific glycoproteins described here plays a role in olfactory reception.
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