ArticleBiophysical journal1978
Ionic channels in excitable membranes. Current problems and biophysical approaches.
Article in Biophysical journal, 1978. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed.
- Topological Doping of Charged Bottlebrush Polymers for Efficient Artificial Ion Channels.Polymer science & technology (Washington, D.C.) · 2026Article
- Integrated Screening Cascades for Ion-Channel Drug Discovery: Linking Structure, Electrophysiology, Safety Pharmacology, and Human-Relevant Models.International journal of molecular sciences · 2026Review
- Germ layer-specific interaction of ion channels and transporters controls membrane potential and left-right patterning in Xenopus tropicalis.Communications biology · 2026Article
- Lipid trapping slows ball-and-chain inactivation in a calcium-activated potassium channel.Nature communications · 2026Article
- KArchiv der Pharmazie · 2026Review
- Ligand Binding Dynamics of Ion Channels and GPCRs Using Single-Molecule Fluorescence.Annual review of biophysics · 2026Review
- Hydrophobic and lipid-mediated gating mechanism revealed by low-conductance MthK mutants.bioRxiv : the preprint server for biology · 2026Article
- Pore size dynamics control complex volume swelling in pyroptosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level.Biophysical journal · 2026Article
- The cornea-trigeminal axis: potassium channels as master regulators of ocular surface homeostasis and sensory transduction.Frontiers in cell and developmental biology · 2026Review
- Enhanced information processing in the human neocortex: cellular mechanisms and translational perspectives.Frontiers in synaptic neuroscience · 2026Review
- The effect of clinically relevant changes in extracellular electrolyte concentrations on human atrial arrhythmias.Communications medicine · 2025Article
- Addressing the challenges of immunogenicity, heterogeneity and tumorigenicity in the clinical translation of human embryonic stem cells.Stem cell research & therapy · 2025Review
- Article
- MutantMicrobiology spectrum · 2025Article
- Interaction-driven giant electrostatic modulation of ion permeation in atomically small capillaries.Nature communications · 2025Article
- Quantum Cardiovascular Medicine: From Hype to Hope-A Critical Review of Real-World Applications.Journal of clinical medicine · 2025Review
- Cvill6 and Cvill7: Potent and Selective Peptide Blockers of Kv1.2 Ion Channel Isolated from Mexican ScorpionToxins · 2025Article
- Investigate channel rectifications and neural dynamics by an electrodiffusive Gauss-Nernst-Planck approach.PLoS computational biology · 2025Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ionic channels are gated aqueous pores whose conformational changes are driven by the electric field in the membrane. Gating may be studied by three electrical methods: ionic current transients, ionic current fluctuations, and "gating current," and probably occurs through a series of conformational changes in the channel leading to an all-or-nothing opening of the pore. When the potential is held constant, the gating steps come to equilibrium rather than reaching an energy-dissipating, cyclic steady state. The kinetic models now in use eventually need to be changed to correct disagreements with several recent studies. Diffusion of ions through open channels is very fast but involves many interactions of ions, pore, and solvent that lead to ionic selectivity, saturation, block, and flux coupling. Our description of the ionic fluxes can be improved by abandoning continuum models in favor of more structured ones. Problems to be solved include determining how many ions occupy a channel at once and what to be solved include determining how many ions occupy a channel at once and what kind of energy barriers they must cross in traversing the membrane. Ultimately we will need to know the chemical structure of the whole system to understand how it functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.