ArticleNucleic acids research1984
Expression of the genes coding for the skeletal muscle and cardiac actions in the heart.
Article in Nucleic acids research, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 156 citations in OpenAlex.
- CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart.Genes & development · 2022Article
- Cardiac foetal reprogramming: a tool to exploit novel treatment targets for the failing heart.Journal of internal medicine · 2020Review
- Farewell to Professor David Yaffe - A pillar of the myogenesis field.European journal of translational myology · 2020Article
- Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development.Journal of molecular and cellular cardiology · 2017Article
- HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes.Epigenetics · 2015Article
- Mesenchymal Stem Cells for Cardiac Regenerative Therapy: Optimization of Cell Differentiation Strategy.Stem cells international · 2015Review
- Engineered Human Muscle Tissue from Skeletal Muscle Derived Stem Cells and Induced Pluripotent Stem Cell Derived Cardiac Cells.International journal of tissue engineering · 2013Article
- Developmental expression of the alpha-skeletal actin gene.BMC evolutionary biology · 2008Article
- The cardiac isoform of alpha-actin in regenerating and atrophic skeletal muscle, myopathies and rhabdomyomatous tumors: an immunohistochemical study using monoclonal antibodies.Virchows Archiv : an international journal of pathology · 2006Article
- Recent insights into cardiac hypertrophy and left ventricular remodeling.Current heart failure reports · 2006Review
- Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Effects of an AT1 receptor antagonist, an ACE inhibitor and a calcium channel antagonist on cardiac gene expressions in hypertensive rats.British journal of pharmacology · 1996Article
- Segregation of cardiac and skeletal muscle-specific regulatory elements of the beta-myosin heavy chain gene.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Degeneration of skeletal and cardiac muscles in c-myb transgenic mice.Transgenic research · 1993Article
- Contractile protein gene expression in serum-free cultured adult rat cardiac myocytes.Pflugers Archiv : European journal of physiology · 1993Article
- Evolution of the chordate muscle actin gene.Journal of molecular evolution · 1993Article
- Different regulatory sequences control creatine kinase-M gene expression in directly injected skeletal and cardiac muscle.Molecular and cellular biology · 1993Article
- Phorbol esters selectively downregulate contractile protein gene expression in terminally differentiated myotubes through transcriptional repression and message destabilization.The Journal of cell biology · 1991Article
- Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts.The Journal of clinical investigation · 1991Article
- Effect of thyroid hormone on the accumulation of mRNA for skeletal and cardiac alpha-actin in hearts from normal and hypophysectomized rats.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Several types of evidence indicate that the gene coding for the skeletal muscle actin is expressed in the rat heart: 1) A recombinant plasmid containing an insert with a nucleotide sequence identical to that of the homologous region of skeletal muscle actin gene was isolated from a cDNA library prepared on rat cardiac mRNA template. 2) Using specific probes it was found that the hearts of newborn rats contain a significant amount of skeletal muscle actin mRNA. The quantity of this mRNA in the heart decreases during development. 3) The skeletal muscle actin gene is DNAase I sensitive in nuclei from rat heart tissue. A plasmid containing a cDNA insert homologous to a part of the cardiac actin mRNA was isolated and sequenced. It was found that in spite of the great similarity between the amino acid sequence of the skeletal muscle and cardiac actins, the nucleotide sequences of the two mRNAs are considerably divergent. There is only limited sequence homology between the 3' untranslated regions of the two mRNAs. However, there is an extensive sequence homology between the 3' untranslated regions of the rat and human cardiac mRNAs, suggesting a functional role for this region of the gene or mRNA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.