ArticleThe EMBO journal1984
A major heat-shock protein defined by a monoclonal antibody.
Article in The EMBO journal, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- The interaction of heat shock proteins with cellular membranes: a historical perspective.Cell stress & chaperones · 2021Review
- Hsp70 localizes differently from chaperone Hsc70 in mouse mesoangioblasts under physiological growth conditions.Journal of molecular histology · 2008Article
- The heat shock cognate protein from Dictyostelium affects actin polymerization through interaction with the actin-binding protein cap32/34.The EMBO journal · 1993Article
- Transcriptional repression by the Rb-related protein p107.Molecular biology of the cell · 1993Article
- Thermoprotection of a functional epithelium: heat stress effects on transepithelial transport by flounder renal tubule in primary monolayer culture.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Cell cycle-dependent association of HSP70 with specific cellular proteins.The Journal of cell biology · 1989Article
- Cytoplasmic distribution of heat shock proteins in soybean.Plant physiology · 1988Article
- A hsp70-related gene is constitutively highly expressed in testis of rat and mouse.Molecular biology reports · 1987Article
- Heat shock and the heat shock proteins.The Biochemical journal · 1986Review
- The dynamic state of heat shock proteins in chicken embryo fibroblasts.The Journal of cell biology · 1986Article
- Heat shock increases the synthesis of the poly(A)-binding protein in HeLa cells.Proceedings of the National Academy of Sciences of the United States of America · 1985Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A monoclonal antibody reacts with a polypeptide of 68 000 mol. wt. (p68) that accumulates to high levels during heat shock. The intracellular distribution of this antigen in normal and heat-shocked cells has been studied. It is a major component of non-stressed cells, where it is located predominantly in the cytoplasm, but also occurs in the nucleus. The nuclear accumulation is growth regulated, in that exponentially growing cells have strong nuclear immunofluorescence and confluent cells little. It is concentrated at the leading edge of motile fibroblasts and co-distributes with actin-containing microfilaments. Heat shock causes cytoplasmic and nuclear accumulation and there is new deposition in the periphery of cells. In normal cells the antigen in the nucleus is located in the nuclear lamina and matrix which increases during heat shock. The distribution of this molecule and the structures with which it interacts suggests that it is important in mediating the effects of heat shock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.