ArticleThe American journal of pathology1984
Effects of iron overload on bone remodeling in pigs.
Article in The American journal of pathology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 108 citations in OpenAlex.
- Serum ferritin levels are positively associated with bone mineral density in elderly Korean men: the 2008-2010 Korea National Health and Nutrition Examination Surveys.Journal of bone and mineral metabolism · 2014Trial
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- [Liver cirrhosis and secondary osteoporosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021Review
- Carbonyl iron and iron dextran therapies cause adverse effects on bone health in juveniles with chronic kidney disease.Kidney international · 2020Article
- Bone Diseases in Patients with Chronic Liver Disease.International journal of molecular sciences · 2019Review
- Bone Effects of Binge Alcohol Drinking Using Prepubescent Pigs as a Model.Alcoholism, clinical and experimental research · 2018Article
- Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Decreased Bone Formation Explains Osteoporosis in a Genetic Mouse Model of Hemochromatosiss.PloS one · 2016Article
- Low-intensity pulsed ultrasound treatment as an alternative to vascular bone graft surgery for a 5-year-long ulnar non-union in a patient with haemochromatosis.BMJ case reports · 2015Article
- Reducing iron accumulation: A potential approach for the prevention and treatment of postmenopausal osteoporosis.Experimental and therapeutic medicine · 2015Article
- Skeletal and soft tissue response to automated, continuous, curvilinear distraction osteogenesis.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2014Article
- Osteoporosis and fractures in liver disease: relevance, pathogenesis and therapeutic implications.World journal of gastroenterology · 2014Review
- Automated continuous distraction osteogenesis may allow faster distraction rates: a preliminary study.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2013Article
- Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Bone status in a mouse model of genetic hemochromatosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Article
- Article
- Iron and menopause: does increased iron affect the health of postmenopausal women?Antioxidants & redox signaling · 2009Article
- Association between iron overload and osteoporosis in patients with hereditary hemochromatosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Article
- Bisphosphonates in the treatment of thalassemia-associated osteoporosis.Journal of endocrinological investigation · 2008Review
- Bone mineral density in men with genetic hemochromatosis and HFE gene mutation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2005Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For study of the effects of an iron overload on bone remodeling, 5 control pigs were compared with 5 pigs given a total dose of 10.8 g of parenteral iron in 36 days. Treated pigs developed an iron tissue overload demonstrated by a marked increase in bone and liver iron. Except for a modest increase in SGOT, there was no biochemical or histologic sign of liver damage. Serum levels of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were unchanged in the treated pigs. There was no accumulation of iron in the parathyroid glands and the serum immunoreactive parathyroid hormone level was unchanged in the treated animals. Bone histomorphometry after double tetracycline labeling showed that in the treated pigs osteoblast cell surfaces, double and total labeled surfaces, appositional rate, and formation at tissue level were significantly decreased, and reversal surfaces were increased. Mineralization was not impaired because the osteoid thickness was unchanged. From the morphometric measurements it was concluded that osteoblast recruitment and the collagen synthesis rate were decreased. Mean wall thickness, which indicates the amount of bone synthesized, was also lowered. In contrast, the osteoclastic resorption surfaces and the depth of lacunae resulting from osteoclast resorption were unchanged by treatment. Despite this imbalance between formation and resorption, trabecular bone mass estimated on trabecular bone volume and bone ash was unchanged after 36 days' treatment. Perls' stain revealed that iron deposits were present in osteoblast and osteoclast cells and also inside the bone matrix, because there was a linear deposit along the trabecular surfaces, cement line, and osteoid-mineralized bone interface. Therefore, because treatment induced no modification of the major humoral regulators of bone metabolism, it is suggested that iron, which was present in bone cells and matrix, could play a role in bone remodeling.
Indexed as
Identifiers
6476075PMC1900459W1973628498What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.