ArticleClinical and experimental immunology1984
Heterogeneity of human eosinophils. II. Variability of respiratory burst activity related to cell density.
Article in Clinical and experimental immunology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Eosinophils as Drivers of Severe Eosinophilic Asthma: Endotypes or Plasticity?International journal of molecular sciences · 2021Review
- Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity.Circulation research · 2020Review
- Recent advances in understanding eosinophil biology.F1000Research · 2017Review
- Constitutive production of granulocyte/macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Production of platelet-activating factor by human normodense and hypodense eosinophils.Lipids · 1991Article
- Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.The Journal of clinical investigation · 1991Article
- Characterization of a receptor for interleukin 5 on human eosinophils: variable expression and induction by granulocyte/macrophage colony-stimulating factor.The Journal of experimental medicine · 1990Article
- A morphometric study of normodense and hypodense human eosinophils that are derived in vivo and in vitro.The American journal of pathology · 1990Article
- The effects of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 on the secretory capacity of human blood eosinophils.Clinical and experimental immunology · 1990Article
- Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea-pigs: the effect of anti-asthma drugs.British journal of pharmacology · 1990Article
- Inhibition of neutrophil and eosinophil induced chemotaxis by nedocromil sodium and sodium cromoglycate.British journal of pharmacology · 1990Article
- The IgE receptor of eosinophils.Springer seminars in immunopathology · 1990Review
- The role of eosinophils in asthma.Lung · 1990Review
- Density heterogeneity of eosinophil leucocytes: induction of hypodense eosinophils by platelet-activating factor.Immunology · 1989Article
- Alteration in the density, morphology, and biological properties of eosinophils produced by bullous pemphigoid blister fluid.Archives of dermatological research · 1989Article
- Platelet-activating factor induces eosinophil peroxidase release from purified human eosinophils.Immunology · 1988Article
- Autoreactive eosinophils associated with spontaneous autocytotoxicity in bronchial asthma.Agents and actions · 1988Article
- Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3.The Journal of clinical investigation · 1988Article
- Eosinophils. Assays and interpretation.Clinical reviews in allergy · 1988Review
- An improved method for the inhibition of endogenous peroxidase non-deleterious to lymphocyte surface markers. Application to immunoperoxidase studies on eosinophil-rich tissue preparations.The Histochemical journal · 1987Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent work has suggested that there may be heterogeneity amongst human eosinophils. In order to study this further, blood and tissue eosinophils were separated by density gradient centrifugation in discontinuous gradients of metrizamide. Blood eosinophils were obtained from 16 patients with blood eosinophil counts above 1 X 10(9)/l. Resident eosinophils were isolated from alveolar fluid in three of these patients and from pleural effusion in two others. A large proportion of the eosinophils in these patients were of light buoyant density (hypodense) and a high percentage of these showed morphological evidence of hypogranulation. Hypodense eosinophils had a reduced capacity to reduce nitroblue tetrazolium or develop chemiluminescence after stimulation with phorbol myristate acetate. It was concluded that there is structural and metabolic heterogeneity amongst blood and tissue eosinophils in patients with a variety of eosinophilic disorders.
Indexed as
Identifiers
6467687PMC1536255What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.