ArticleThe American journal of pathology1983
Horse eosinophil degranulation induced by the ionophore A23187. Ultrastructure and role of phospholipase A2.
Article in The American journal of pathology, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Tethering forces of secretory granules measured with optical tweezers.Biophysical journal · 2008Article
- Differential regulation of granule-to-granule and granule-to-plasma membrane fusion during secretion from rat pituitary lactotrophs.The Journal of cell biology · 2000Article
- Regulation of granule size in human and horse eosinophils by number of fusion events among unit granules.The Journal of physiology · 1995Article
- Focal exocytosis by eosinophils--compound exocytosis and cumulative fusion.The EMBO journal · 1993Article
- Eosinophils: a review.Veterinary research communications · 1992Review
- Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils.The Journal of experimental medicine · 1990Article
- Relationship between arachidonate generation and exocytosis in permeabilized mast cells.The Biochemical journal · 1990Article
- Article
- Uptake of human eosinophil peroxidase by human neutrophils.The American journal of pathology · 1986Article
- Multigranular exocytosis induced by phospholipase A2-activators, melittin and mastoparan, in rat anterior pituitary cells.Cell and tissue research · 1986Article
- Cytochemical studies on the localization and functional properties of calcium in anterior pituitary cells.Histochemistry · 1984Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Horse eosinophils stimulated with the calcium ionophore A23187 were examined by transmission and scanning electron microscopy. Secretion was characterized by granule movement to the cell periphery and fusion of adjacent granules. The granules became swollen and less electron-dense as their contents were released into large intracellular vacuoles, which opened to the outside of the cell through surface pores. A23187-induced eosinophil peroxidase (EPO) release, as measured by guaiacol oxidation, was blocked by eicosa-5,8,11,14-tetraynoic acid (ETYA) (which inhibits both the cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism) but not by indomethacin (which inhibits only the cyclooxygenase pathway). Highly purified porcine phospholipase A2 induced noncytotoxic eosinophil degranulation (as measured by the release of EPO without the concomitant release of the cytoplasmic marker lactate dehydrogenase), which was blocked by pretreatment of the enzyme with the phospholipase A2 inhibitor 4-bromophenacyl bromide. These results suggest that calcium-dependent activation of phospholipase A2 and generation of lipoxygenase products of arachidonic acid metabolism are important in the initiation of eosinophil degranulation.
Indexed as
Identifiers
6407328PMC1916278W135890361What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.