ArticleMolecular and cellular biology1984
Cell cycle-dependent expression of thymidylate synthase in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 79 citations in OpenAlex.
- Cell cycle-regulated transcription: effectively using a genomics toolbox.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Mapping and expression of a bifunctional thymidylate synthase, dihydrofolate reductase gene from maize.Plant molecular biology · 1999Article
- Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity.British journal of cancer · 1998Article
- Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity.The EMBO journal · 1996Article
- Transcription of mutS and mutL-homologous genes in Saccharomyces cerevisiae during the cell cycle.Molecular & general genetics : MGG · 1996Article
- Regulation of mouse thymidylate synthase gene expression in growth-stimulated cells: upstream S phase control elements are indistinguishable from the essential promoter elements.Nucleic acids research · 1995Article
- Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells.British journal of cancer · 1995Article
- A member of a novel family of yeast 'zn-finger' proteins mediates the transition from stationary phase to cell proliferation.The EMBO journal · 1994Article
- An impaired RNA polymerase II activity in Saccharomyces cerevisiae causes cell-cycle inhibition at START.Molecular & general genetics : MGG · 1993Article
- MCB elements and the regulation of DNA replication genes in yeast.Current genetics · 1993Review
- Budding yeast mutants showing constitutive basal levels of expression of DNA synthesis genes.Molecular & general genetics : MGG · 1993Article
- Cell cycle expression of two replicative DNA polymerases alpha and delta from Schizosaccharomyces pombe.Molecular biology of the cell · 1993Article
- Cell cycle control of DNA synthesis in budding yeast.Nucleic acids research · 1992Review
- A meristem-related gene from tomato encodes a dUTPase: analysis of expression in vegetative and floral meristems.The Plant cell · 1992Article
- Identification and purification of a factor that binds to the Mlu I cell cycle box of yeast DNA replication genes.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles.The Journal of cell biology · 1991Article
- The yeast DNA ligase gene CDC9 is controlled by six orientation specific upstream activating sequences that respond to cellular proliferation but which alone cannot mediate cell cycle regulation.Nucleic acids research · 1991Article
- Characterization of a short, cis-acting DNA sequence which conveys cell cycle stage-dependent transcription in Saccharomyces cerevisiae.Molecular and cellular biology · 1991Article
- Induction of yeast histone genes by stimulation of stationary-phase cells.Molecular and cellular biology · 1990Article
- Cloning and cell cycle-dependent expression of DNA replication gene dnaC from Caulobacter crescentus.Journal of bacteriology · 1990Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Synchronous populations of Saccharomyces cerevisiae cells, generated by two independent methods, have been used to show that thymidylate synthase, in contrast to the vast majority of cellular proteins thus far examined, fluctuates periodically during the S. cerevisiae cell cycle. The enzyme, as assayed by two different methods, accumulated during S period and peaked in mid to late S phase, and then its level dropped. These observations suggest that both periodic synthesis and the instability of the enzyme contribute to the activity profile seen during the cell cycle. Accumulation of thymidylate synthase is determined at the level of its transcript, with synthase-specific mRNA levels increasing at least 10-fold to peak near the beginning of S period and then falling dramatically to basal levels after the onset of DNA synthesis. This mRNA peak coincided with the time during the cell cycle when thymidylate synthase levels were increasing maximally and immediately preceded the peak of DNA synthesis, for which the enzyme provides precursor dTMP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.