ArticleClinical and experimental immunology1984
Detection of IgG rheumatoid factor secreting cells in autoimmune MRL/1 mice: a kinetic study.
Article in Clinical and experimental immunology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- IgM, IgG, and IgA rheumatoid factors in pigeon hypersensitivity pneumonitis.Journal of clinical laboratory analysis · 2007Article
- Augmented levels of macrophage and Th1 cell-related cytokine mRNA in submandibular glands of MRL/lpr mice with autoimmune sialoadenitis.Clinical and experimental immunology · 1998Article
- Vitamin A deficiency predisposes to Staphylococcus aureus infection.Infection and immunity · 1996Article
- Preferential induction of septic arthritis and mortality by superantigen-producing staphylococci.Infection and immunity · 1995Article
- Immunopathological features of rat Staphylococcus aureus arthritis.Infection and immunity · 1994Article
- Histopathological and serological progression of experimental Staphylococcus aureus arthritis.Infection and immunity · 1992Article
- Frequency and phenotypic feature of autoantibody-producing cell precursors in the preclinical stage of murine lupus.Immunology · 1990Article
- Differential effects of captopril and enalapril, two angiotensin converting enzyme inhibitors, on immune reactivity in experimental lupus disease.Agents and actions · 1990Article
- Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.Clinical and experimental immunology · 1990Article
- Features of renal vasculitis in autoimmune MRL lpr/lpr mice: phenotypes and functional properties of infiltrating cells.Clinical and experimental immunology · 1988Article
- Sialadenitis in the MRL-l mouse: morphological and immunohistochemical characterization of resident and infiltrating cells.Immunology · 1987Article
- Effects of LS-2616 administration upon the autoimmune disease of (NZB x NZW) F1 hybrid mice.Immunology · 1986Article
- Individual variation of anti-Sm autoantibodies in the MRL/MP-lpr/lpr mouse: age-related increase in diversity.Clinical and experimental immunology · 1986Article
- Patterns of autoreactivity to collagen type II in autoimmune MRL/l mice.Clinical and experimental immunology · 1986Article
- Simultaneous induction of rheumatoid factor- and antigen-specific antibody-secreting cells during the secondary immune response in man.Clinical and experimental immunology · 1985Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetics of appearance of cells secreting IgG rheumatoid factor (IgG RF) has been studied in MRL/l mice by means of the ELISPOT assay, a new immunoenzyme procedure. Mice of the MRL/l strain spontaneously develop an autoimmune disease associated with arthritic manifestations. IgG RF secreting splenocytes were first detected at the clinical onset of the disease at the age of 3 months. Peak frequencies of IgG RF secreting cells amounting to almost 10% of the total number of IgG secreting cells were observed at later stages. The appearance of IgG RF secreting cells was preceded by at least 1 month by elevated levels of circulating immune complexes and abnormally high numbers of IgG secreting cells. The frequencies of IgG RF secreting cells and of IgG secreting splenocytes did not follow each other at least not during the first 3 months preceding the onset of clinical disease. The data presented suggest that IgG RF production in MRL/l mice is not triggered as part of an early stage of polyclonal activation but could be induced by IgG containing immune complexes.
Indexed as
Identifiers
6383669PMC1576976W59134274What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.