ArticleThe American journal of pathology1984
The organization of microtubules and microtubule coils in giant platelet disorders.
Article in The American journal of pathology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry.Blood advances · 2022Article
- Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.Cell death & disease · 2021Article
- Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation.BMC biology · 2018Article
- Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.Nature communications · 2018Article
- Article
- Does size matter in platelet production?Blood · 2012Review
- Microtubule and cortical forces determine platelet size during vascular platelet production.Nature communications · 2012Article
- FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.Blood · 2011Article
- Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.Haematologica · 2009Article
- Hereditary types of thrombocytopenia with giant platelets and inclusion bodies in the leukocytes.Blut · 1990Article
- Of mice and men: Relevance of cellular and molecular characterizations of myosin IIA to MYH9-related human disease.Cell adhesion & migrationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Normal human platelets are characteristically discoid in shape. The lentiform appearance is supported by a circumferential band of microtubules lying just under the cell membrane along its greatest circumference. Some of the cells from patients with giant platelet disorders are also disk-shaped, but the majority of their huge platelets are spherical. In the present study platelets from patients with the Gray platelet syndrome (GPS), May-Hegglin anomaly (MHA), and Epstein's syndrome (ES) were examined in thin sections and negatively stained whole mounts, and by indirect immunofluorescence with a monoclonal antibody to tubulin for determination of the organization of their microtubule systems. Many GPS platelets and some ES and MHA platelets were discoid and contained circumferential bundles of microtubules. The number of coils in the band was increased 10-20-fold. Giant spherical platelets also contained increased numbers of individual microtubules and coils, but they were not organized into circumferential bundles. Immunofluorescence revealed an organization of assembled tubulin in the huge cells, suggestive of balls of yarn. Failure of the microtubules to organize into a circumferential band may explain why the majority of the huge cells have a spherical form.
Indexed as
Identifiers
6383063PMC1900466W126813486What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.