ArticleZeitschrift fur Parasitenkunde (Berlin, Germany)1984
A monoclonal antibody raised against adult Schistosoma mansoni which recognizes a surface antigen on schistosomula.
Article in Zeitschrift fur Parasitenkunde (Berlin, Germany), 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 36 citations in OpenAlex.
- Leishmania major-like antigen for specific and sensitive serodiagnosis of human and canine visceral leishmaniasis.Clinical and diagnostic laboratory immunology · 2002Article
- A cDNA clone encoding part of the major 25,000-dalton surface membrane antigen of adult Schistosoma mansoni.Parasitology research · 1989Article
- Surface antigen detected by a Schistosoma mansoni monoclonal antibody in worm extracts and kidney deposits of infected mice and hamsters.Infection and immunity · 1986Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A monoclonal antibody has been raised by immunizing a mouse with an isolated tegumental preparation of adult Schistosoma mansoni. The hybridoma designated NIMP/M.47, secreted an IgG2a antibody which was positive by indirect immunofluorescence with live schistosomula of S. mansoni, but not with live schistosomula of S. bovis, or with other living life cycle stages of S. mansoni. In complement-dependent, or cell-mediated in vitro cytotoxicity assays, the monoclonal antibody mediated levels of schistosomular killing as high as those obtained with sera from infected mice. No significant protection, however, was obtained in passive transfer experiments. NIMP/M47 was specific for a 20,000 dalton polypeptide in the schistosomular surface, which was also recognized by serum from infected mice.
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Registered trials
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