ArticleProceedings of the National Academy of Sciences of the United States of America1984
Identification of a labile protein involved in the G1-to-S transition in Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle.PloS one · 2019Article
- The PHR Family: The Role of Extracellular Transglycosylases in Shaping Candida albicans Cells.Journal of fungi (Basel, Switzerland) · 2017Review
- In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets.Anti-cancer agents in medicinal chemistry · 2008Review
- Transcript accumulation of the GGP1 gene, encoding a yeast GPI-anchored glycoprotein, is inhibited during arrest in the G1 phase and during sporulation.Current genetics · 1993Article
- Physiological analysis of mutants indicates involvement of the Saccharomyces cerevisiae GPI-anchored protein gp115 in morphogenesis and cell separation.Journal of bacteriology · 1993Article
- Cyclic AMP, nuclear protein kinase and the PY815 cell cycle.Molecular and cellular biochemistry · 1985Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
The biochemical nature of the start process that commits budding yeast to DNA synthesis is not known. Kinetic evidence has suggested recently that short-lived protein(s) may have to accumulate to a critical level before the cell cycle may progress towards DNA synthesis and cell division. We investigated by high-resolution two-dimensional electrophoresis whether, in a cdc25-1 mutant strain of Saccharomyces cerevisiae that had been blocked at the regulatory step called "start" by growth at a restrictive temperature, short-lived proteins are synthesized during the recovery of growth at a permissive temperature. Of the approximately equal to 500 proteins resolved by the two-dimensional electrophoresis, 6 were short-lived. Only one of them (Mr = 100,000, pI approximately equal to 4.8-5) appears to be specifically made during the G1-to-S transition at start. A regulatory role for cell cycle progression in yeast is suggested for this protein, p100.
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