ArticleInfection and immunity1984
Killing of human malaria parasites by macrophage secretory products.
Article in Infection and immunity, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 130 citations in OpenAlex.
- The antimalarial profiling ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes.Scientific reports · 2017Article
- Placental Malaria: A New Insight into the Pathophysiology.Frontiers in medicine · 2017Review
- Article
- Article
- Association of high plasma TNF-alpha levels and TNF-alpha/IL-10 ratios with TNF2 allele in severe P. falciparum malaria patients in Sri Lanka.Pathogens and global health · 2013Article
- Role of oxidative stress and apoptosis in the placental pathology of Plasmodium berghei infected mice.PloS one · 2012Article
- Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination.Clinical microbiology reviews · 2011Review
- Antiplasmodial activity of [(aryl)arylsulfanylmethyl]Pyridine.Antimicrobial agents and chemotherapy · 2008Article
- Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program.Infection and immunity · 2007Article
- Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections.Infection and immunity · 2005Article
- Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide.Infection and immunity · 2004Article
- The purine salvage enzyme hypoxanthine guanine xanthine phosphoribosyl transferase is a major target antigen for cell-mediated immunity to malaria.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum.Infection and immunity · 2003Article
- Cooperation between reactive oxygen and nitrogen intermediates in killing of Rhodococcus equi by activated macrophages.Infection and immunity · 2000Article
- Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione.The Biochemical journal · 2000Article
- Phagocytosis does not play a major role in naturally acquired transmission-blocking immunity to Plasmodium falciparum malaria.Infection and immunity · 1999Article
- Oxidative stress in malaria; implications for prevention and therapy.Pharmacy world & science : PWS · 1996Review
- Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting alpha-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes.The Journal of clinical investigation · 1994Article
- Potentiation of chloroquine activity against Plasmodium falciparum by the peroxidase-hydrogen peroxide system.Antimicrobial agents and chemotherapy · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The susceptibility of the human malaria parasite, Plasmodium falciparum, to killing in vitro by macrophage secretory products was investigated. The effect of O2 radicals and tumor necrosis factor on parasite viability was assessed both morphologically and by following the uptake of [3H]hypoxanthine. H2O2 produced by the interaction of glucose and glucose oxidase was found to reduce viability; this effect was reversed by the addition of exogenous catalase. Further studies indicated that the catalase level within the erythrocyte was not altered upon parasite invasion. O2 radicals produced during the xanthine-xanthine oxidase interaction also killed P. falciparum. The addition of various O2 radical scavengers (including catalase) did not reverse this effect; therefore, it was not possible to determine which of the O2 radicals were involved in the killing process. Samples from three different sources containing tumor necrosis factor, a nonspecific soluble mediator derived from Mycobacterium bovis BCG-activated macrophages treated with endotoxin, also killed the parasite. There was no evidence that tumor necrosis factor or the products of the xanthine-xanthine oxidase interaction caused damage to the erythrocyte membrane that could be implicated as an important aspect of the killing process. These findings all strongly suggest that such macrophage products play an important role in immunity to malaria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.