ArticleThe Journal of cell biology1983
Epinemin: a new protein associated with vimentin filaments in non-neural cells.
Article in The Journal of cell biology, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 64 citations in OpenAlex.
- Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains.The Biochemical journal · 1999Article
- Immunocytochemical demonstration of a new vimentin-associated protein in 3T3 fibroblasts.The Histochemical journal · 1996Article
- Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern.Molecular and cellular biology · 1994Article
- Purification and properties of transgelin: a transformation and shape change sensitive actin-gelling protein.The Journal of cell biology · 1993Article
- A novel microtubule-binding motif identified in a high molecular weight microtubule-associated protein from Trypanosoma brucei.The Journal of cell biology · 1992Article
- A polypeptide of 59 kDa is associated with bundles of cytoplasmic filaments in Neurospora crassa.The Biochemical journal · 1990Article
- Identification of new actin-associated polypeptides that are modified by viral transformation and changes in cell shape.The Journal of cell biology · 1988Article
- Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins.The Journal of cell biology · 1988Article
- Molecular specialization of astrocyte processes at nodes of Ranvier in rat optic nerve.The Journal of cell biology · 1986Article
- alpha-Internexin, a 66-kD intermediate filament-binding protein from mammalian central nervous tissues.The Journal of cell biology · 1985Article
- Are cross-bridging structures involved in the bundle formation of intermediate filaments and the decrease in locomotion that accompany cell aging?The Journal of cell biology · 1985Article
- A 300,000-mol-wt intermediate filament-associated protein in baby hamster kidney (BHK-21) cells.The Journal of cell biology · 1985Article
- Distribution of epinemin in colloidal gold-labelled, quick-frozen, deep-etched cytoskeletons.The Journal of cell biology · 1984Article
- A major heat-shock protein defined by a monoclonal antibody.The EMBO journal · 1984Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
In this report I describe a new protein, defined by a monoclonal antibody, which is associated with vimentin filaments in a variety of cultured cells and in skeletal muscle. By immunofluorescence it is absent in smooth muscle, in cells without vimentin, and in neural vimentin containing cells. This protein has a molecular weight of 44,500, a pl of 5, a two-dimensional tryptic peptide fingerprint pattern different from vimentin, is unrelated to actin by Cleveland peptide analysis and by light and electron microscopy, and is not recognized by either a polyclonal antivimentin antibody (Frank, E.D., and L. Warren, 1981, Proc. Natl. Acad. Sci. USA, 78:3020-3024) or a monoclonal antibody against all classes of intermediate filaments (Pruss, R.M., R. Mirsky, M.C. Raff, R. Thorpe, A.J. Dowding, and B.H. Anderton, 1981, Cell, 27:419-428). The protein is resistant to nonionic detergent extraction, is soluble in high salt and can thus be removed from vimentin filaments, but fragments with vimentin in either low salt or anionic detergent and collapses with vimentin in colchicine-treated cells. By light microscopy, the distribution of the protein is indistinguishable from vimentin filaments and appears uniform along them. In contrast, immunoferritin electron microscopy reveals that the molecule is distributed in an intermittent pattern on vimentin filaments. Adopting the terminology of Granger and Lazarides (1980, Cell, 30:263-275), the molecule is called epinemin, meaning "upon filaments."
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