ArticleThe Journal of experimental medicine1983
Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response.
Article in The Journal of experimental medicine, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 137 citations in OpenAlex.
- Rheumatoid factor IgM autoantibodies control IgG homeostasis.Frontiers in immunology · 2022Article
- Safety of Multiple Vaccinations and Durability of Vaccine-Induced Antibodies in an Italian Military Cohort 5 Years after Immunization.Biomedicines · 2021Article
- Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis.Arthritis research & therapy · 2017Article
- Elevated levels of antibodies against xenobiotics in a subgroup of healthy subjects.Journal of applied toxicology : JAT · 2015Article
- Neutralization-Enhancing RF Antibodies for HIV Vaccines.Frontiers in immunology · 2014Review
- Histidine-rich glycoprotein prevents the formation of insoluble immune complexes by rheumatoid factor.Immunology · 1999Article
- Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Human monoclonal rheumatoid factors: incidence of cross-reactions with tissue components and correlation with VH gene usage.Immunology · 1994Article
- Rheumatoid factor production by mononuclear cells derived from different sites of patients with rheumatoid arthritis.Clinical and experimental immunology · 1993Article
- Suppression of anti-erythrocyte autoantibody-producing B cells by a physiological IgG-anti-F(ab')2 antibody and escape from suppression by tumour transformation; a model relevant for the pathogenesis of autoimmune haemolytic anaemia.Clinical and experimental immunology · 1993Article
- Rheumatoid factors in mice bearing the lpr or gld mutation. Selective production of rheumatoid factor cryoglobulins in MRL/MPJ-lpr/lpr mice.Clinical and experimental immunology · 1992Article
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.The Journal of experimental medicine · 1991Article
- Rheumatoid factor (RF) distribution in periodontal disease.Journal of clinical immunology · 1991Article
- Frequency and phenotypic feature of autoantibody-producing cell precursors in the preclinical stage of murine lupus.Immunology · 1990Article
- In vitro IgG rheumatoid factor production by CD5-negative murine B cells in response to immune complexes of lipopolysaccharide.Clinical and experimental immunology · 1990Article
- Evidence that the Fc region of autologous rabbit IgG isolated before and after hyperimmunization is structurally different: recognition by rheumatoid factor and monoclonal antibodies.Clinical and experimental immunology · 1990Article
- Human IgG anti-F(ab')2 antibodies possess rheumatoid factor activity.Clinical and experimental immunology · 1990Article
- IgG isotype and isotype specificity of murine monoclonal IgG rheumatoid factors.Clinical and experimental immunology · 1990Article
- I-E-linked control of spontaneous rheumatoid factor production in normal mice.The Journal of experimental medicine · 1989Article
- Activation of clones producing self-reactive antibodies by foreign antigen and antiidiotype antibody carrying the internal image of the antigen.The Journal of clinical investigation · 1989Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
A/J mice were found to produce autoreactive IgM anti-IgG1 in response to secondary immunization with a number of protein antigens. No anti-IgG1 was produced after a single such immunization, indicating that antigen: IgG1 antibody complexes were responsible for inducing the autoreactive response. The size of the anti-IgG1 response was in some cases massive and of the same order of magnitude as the response to the foreign immunizing material. No significant anti-IgG2a, anti-IgG2b, or anti-IgG3 response was found in mice producing anti-IgG1. Virtually all of the anti-IgG1 material produced was of the IgM class and bound to the Fc region of autologous IgG1. A component of the anti-IgG1 was shown to be able to distinguish between the two mouse IgG1 allotypes. These results suggest that self-reactive anti-IgG is a common component of the secondary immune response of mice that may have powerful physiological and immunoregulatory effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.