ArticleThe Journal of clinical investigation1983
Prenatal allergic sensitization to helminth antigens in offspring of parasite-infected mothers.
Article in The Journal of clinical investigation, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 130 citations in OpenAlex.
- Maternal IgE Influence on Fetal and Infant Health.Immunological reviews · 2025Review
- Human IgE does not bind to human FcRn.Scientific reports · 2022Article
- Maternal LatentFrontiers in immunology · 2020Observational
- Interferon-Journal of tropical medicine · 2018Article
- IgG Expression upon Oral Sensitization in Association with Maternal Exposure to Ovalbumin.PloS one · 2016Article
- Helminth-induced immune regulation: implications for immune responses to tuberculosis.PLoS pathogens · 2015Article
- Association of in utero sensitization to Schistosoma haematobium with enhanced cord blood IgE and increased frequencies of CD5- B cells in African newborns.The American journal of tropical medicine and hygiene · 2012Article
- Evidence for a peak shift in a humoral response to helminths: age profiles of IgE in the Shuar of Ecuador, the Tsimane of Bolivia, and the U.S. NHANES.PLoS neglected tropical diseases · 2011Article
- Do antenatal parasite infections devalue childhood vaccination?PLoS neglected tropical diseases · 2009Review
- Susceptibility of neonate mice born to Schistosoma mansoni-infected and noninfected mothers to subsequent S. mansoni infection.Parasitology research · 2006Article
- The potential impact of early exposures to geohelminth infections on the development of atopy.Clinical reviews in allergy & immunology · 2004Review
- Influence of maternal filariasis on childhood infection and immunity to Wuchereria bancrofti in Kenya.Infection and immunity · 2003Article
- Filarial antigens impair the function of human dendritic cells during differentiation.Infection and immunity · 2001Article
- Prenatal immune priming in onchocerciasis-onchocerca volvulus-specific cellular responsiveness and cytokine production in newborns from infected mothers.Clinical and experimental immunology · 1999Article
- Neonatal idiotypic exposure alters subsequent cytokine, pathology, and survival patterns in experimental Schistosoma mansoni infections.The Journal of experimental medicine · 1999Article
- Effect of maternal lifestyle on cord blood IgE factor.European journal of epidemiology · 1997Article
- In utero exposure to helminth and mycobacterial antigens generates cytokine responses similar to that observed in adults.The Journal of clinical investigation · 1997Article
- In utero exposure to Onchocerca volvulus: relationship to subsequent infection intensity and cellular immune responsiveness.Infection and immunity · 1996Article
- Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.The Journal of clinical investigation · 1993Article
- Plasmodium falciparum-specific immunoglobulin G (IgG), IgM, and IgE antibodies in paired maternal-cord sera from east Sepik Province, Papua New Guinea.Infection and immunity · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total and filaria-specific immunoglobulin E (IgE) levels were studied in cord blood from infants born in Madras, India, where filariasis and intestinal helminth infections are highly endemic. Increased total IgE levels were observed in 82% of 57 cord sera tested (geometric mean 12.6 ng/ml; range 1-1,900 ng/ml). 33 of these sera also contained IgE antibodies specific for filarial antigens as determined by solid-phase radioimmunoassay. Comparison of ratios of filaria-specific IgE to total IgE in paired maternal and cord sera suggested that cord blood IgE was derived from the fetus in most cases and not from transplacental antibody transfer. Our results suggest that prenatal allergic sensitization to helminth parasites occurs in the tropics. Such sensitization may contribute to the heterogeneity in host immune response and disease expression noted in filariasis and other helminth infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.