ArticleHuman genetics1984
Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes.
Article in Human genetics, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Mitotic Antipairing of Homologous Chromosomes.Results and problems in cell differentiation · 2022Article
- Recollections of a scientific journey published in human genetics: from chromosome territories to interphase cytogenetics and comparative genome hybridization.Human genetics · 2014Article
- Non-random radial higher-order chromatin arrangements in nuclei of diploid human cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2001Article
- Size-dependent positioning of human chromosomes in interphase nuclei.Biophysical journal · 2000Article
- Correlated positioning of homologous chromosomes in daughter fibroblast cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1999Article
- Spatial analysis of intranuclear human repetitive DNA regions by in situ hybridization and digital fluorescence microscopy.The Histochemical journal · 1993Review
- Characterization of centromere arrangements and test for random distribution in G0, G1, S, G2, G1, and early S' phase in human lymphocytes.Human genetics · 1992Article
- Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences.The Journal of cell biology · 1992Article
- The Barr body is a looped X chromosome formed by telomere association.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Article
- Chromosomal in situ suppression hybridization of human gonosomes and autosomes and its use in clinical cytogenetics.Human genetics · 1990Article
- Interphase cytogenetics.Neurochemical research · 1990Review
- Chromosome-specific alpha satellite DNA from the centromere of human chromosome 16.American journal of human genetics · 1989Article
- Somatic pairing of chromosome 1 centromeres in interphase nuclei of human cerebellum.Human genetics · 1989Article
- Chromatin architecture and nuclear RNA.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Rapid detection of human chromosome 21 aberrations by in situ hybridization.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes.Human genetics · 1988Article
- Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries.Human genetics · 1988Article
- Fluorescence in situ hybridization to interphase cell nuclei in suspension allows flow cytometric analysis of chromosome content and microscopic analysis of nuclear organization.Human genetics · 1988Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two cloned repetitive DNA probes, pXBR and CY1, which bind preferentially to specific regions of the human X and Y chromosome, respectively, were used to study the distribution of the sex chromosomes in human lymphocyte nuclei by in situ hybridization experiments. Our data indicate a large variability of the distances between the sex chromosomes in male and female interphase nuclei. However, the mean distance observed between the X and Y chromosome was significantly smaller than the mean distance observed between the two X-chromosomes. The distribution of distances determined experimentally is compared with three model distributions of distances, and the question of a non-random distribution of sex chromosomes is discussed. Mathematical details of these model distributions are provided in an Appendix to this paper. In the case of a human translocation chromosome (Xqter----Xp22.2::Yq11----Yqter) contained in the Chinese hamster X human hybrid cell line 445 X 393, the binding sites of pXBR and CY1 were found close to each other in most interphase nuclei. These data demonstrate the potential use of chromosome-specific repetitive DNA probes to study the problem of interphase chromosome topography.
Indexed as
Identifiers
6336321What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.