ArticleThe Journal of clinical investigation1984
Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man.
Article in The Journal of clinical investigation, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02590614 (Genetic, Dietary and Environmental Influences on Vitamin D Metabolism), which is not on this map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic, Dietary and Environmental Influences on Vitamin D Metabolism
Who cites it
38 citing papers in PubMed, 148 citations in OpenAlex.
- Trial
- Trial
- Seasonal variation in bone metabolism in young healthy subjects.Calcified tissue international · 1991Trial
- Dietary inflammatory index is associated with Vitamin D in CKD patients.International urology and nephrology · 2024Article
- Evaluating the effect of body mass index and 25-hydroxy-vitamin D level on basal cell carcinoma using Mendelian randomization.Scientific reports · 2023Article
- Modulation of cardiometabolic risk and CardioRenal syndrome by oral vitamin DRenal failure · 2022Article
- Article
- Circulatory 25(OH)D and 1,25(OH)eNeurologicalSci · 2021Article
- Weight Loss After RYGB Is Associated with an Increase in Serum Vitamin D in a Population with Low Prevalence of Hypovitaminosis D at Low Latitude.Obesity surgery · 2020Article
- Relationships between circulating 25(OH) vitamin D, leptin levels and visceral adipose tissue volume: results from a 1-year lifestyle intervention program in men with visceral obesity.International journal of obesity (2005) · 2020Article
- Sex Differences of Vitamin D Status across BMI Classes: An Observational Prospective Cohort Study.Nutrients · 2019Observational
- Mobilising vitamin D from adipose tissue: The potential impact of exercise.Nutrition bulletin · 2019Review
- No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Serum vitamin D in patients with mild cognitive impairment and Alzheimer's disease.Brain and behavior · 2018Article
- The cellular selection between apoptosis and autophagy: roles of vitamin D, glucose and immune response in diabetic nephropathy.Endocrine · 2017Article
- Low vitamin D status and obesity: Role of nutritionist.Reviews in endocrine & metabolic disorders · 2017Review
- Causes of Vitamin D Deficiency and Effect of Vitamin D Supplementation on Metabolic Complications in Obesity: a Review.Current obesity reports · 2015Review
- Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men.International journal of obesity (2005) · 2015Article
- Inflammation and vitamin D: the infection connection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Review
- Vitamin D insufficiency is associated with abdominal obesity in urban Asian Indians without diabetes in North India.Diabetes technology & therapeutics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previous in vitro studies in rachitic rat liver suggested that 1,25-dihydroxyvitamin D inhibits the hepatic production of 25-hydroxyvitamin D (25-OHD). An investigation therefore was carried out in eight normal subjects to determine whether concomitant administration of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] would alter the response of serum 25-OHD to challenge with vitamin D. In control studies, vitamin D, 100,000 U/d for 4 d, significantly increased mean serum 25-OHD, from 26.3 +/- 2.9 to 66.7 +/- 12.6 ng/ml (P less than 0.01). In contrast, 1,25(OH)2D3, 2 micrograms/d for 4 d, completely prevented an increase in serum 25-OHD in response to the same dose of vitamin D in the same individuals (25.1 +/- 2.2 vs. 27.4 +/- 5.3 ng/ml, NS). In a post-control study in seven of the normal subjects, vitamin D again significantly increased mean serum 25-OHD, from 18.2 +/- 3.1 to 42.8 +/- 4.7 ng/ml (P less than 0.001). In each of the three studies, mean serum calcium, phosphorus, and creatinine did not change and remained within the normal range. Whereas mean urinary calcium did not change in response to vitamin D alone during the 4 d of the two control studies, it increased significantly in the study in which vitamin D and 1,25(OH)2D3 were given together. A dose-response inhibition of the response of serum 25-OHD to vitamin D by 1,25(OH)2D3 was demonstrated in two of the normal subjects. The results provide evidence that 1,25(OH)2D3 inhibits the hepatic synthesis of its precursor 25-OHD in man.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.