ArticleMolecular and cellular biology1984
Structure of a human smooth muscle actin gene (aortic type) with a unique intron site.
Article in Molecular and cellular biology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 90 citations in OpenAlex.
- Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders.The Journal of pathology · 2017Article
- Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis.The American journal of pathology · 1996Article
- Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.The American journal of pathology · 1994Article
- Reduced levels of topoisomerase II alpha and II beta in a multidrug-resistant lung-cancer cell line.Cancer chemotherapy and pharmacology · 1994Article
- Basic fibroblast growth factor has a differential effect on MyoD conversion of cultured aortic smooth muscle cells from newborn and adult rats.The American journal of pathology · 1993Article
- Exon-intron organization of fish major histocompatibility complex class II B genes.Immunogenetics · 1993Article
- Elevated expression of annexin II (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line.British journal of cancer · 1992Article
- AIDS-associated Kaposi's sarcoma-derived cells in long-term culture express and synthesize smooth muscle alpha-actin.The American journal of pathology · 1991Article
- Cross reaction of antibodies to a glycine/alanine repeat sequence of Epstein-Barr virus nuclear antigen-1 with collagen, cytokeratin, and actin.Annals of the rheumatic diseases · 1991Article
- Cellular ras gene activity is required for full neoplastic transformation by polyomavirus.Journal of virology · 1991Article
- Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts.The Journal of clinical investigation · 1991Article
- Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes.Molecular and cellular biology · 1991Article
- Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation.The Journal of clinical investigation · 1991Article
- Structure and expression of a single actin gene in Volvox carteri.Current genetics · 1990Article
- Diverse soybean actin transcripts contain a large intron in the 5' untranslated leader: structural similarity to vertebrate muscle actin genes.Plant molecular biology · 1990Article
- Evidence that introns arose at proto-splice sites.The EMBO journal · 1989Article
- Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice.Molecular and cellular biology · 1989Article
- The development expression of the rat alpha-vascular and gamma-enteric smooth muscle isoactins: isolation and characterization of a rat gamma-enteric actin cDNA.Molecular and cellular biology · 1988Article
- Nucleotide sequence of a mouse vascular smooth muscle alpha-actin cDNA.Nucleic acids research · 1988Article
- Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.The Journal of clinical investigation · 1988Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recombinant phage containing an actin gene (lambda Ha201) was isolated from a human DNA library and the structure of the actin gene was determined. The amino acid sequences deduced from the nucleotide sequences of lambda Ha201 were compared with those of six actin isoforms; they matched those of bovine aortic smooth muscle actin, except for codon 309, which was valine (GTC) in lambda Ha201 and alanine (GCN) in bovine aortic smooth muscle actin. Southern blot hybridization experiments showed that the gene of normal human cells did not have the TaqI-sensitive site around position 309, whereas half of the genes of HUT14 cells did. These results indicate that one allele of the aortic smooth muscle actin gene in HUT14 cells has a transition point mutation (C----T) at codon 309 and that the amino acid sequences of normal human aorta and bovine smooth muscle actins are probably identical. In addition to the five introns interrupting exons at codons 150, 204, and 267, and between codons 41 and 42 and 327 and 328, which are common to skeletal muscle and cardiac muscle actin genes, the smooth muscle actin gene has two more intron sites between codons 84 and 85 and 121 and 122. The previously unreported intron site between codons 84 and 85 is unique to the smooth muscle actin gene. The intron site between codons 121 and 122 is common to beta-actin genes but is not found in other muscle actin genes. A hypothesis is proposed for the evolutionary pathway of the actin gene family.
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