ArticleProceedings of the National Academy of Sciences of the United States of America1983
Structural organization and expression of human DNA sequences related to the transforming gene of avian myeloblastosis virus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 82 citations in OpenAlex.
- c-MYB and DMTF1 in Cancer.Cancer investigation · 2019Review
- Article
- Proto-oncogene expression in a human chondrosarcoma cell line: HCS-2/8.Japanese journal of cancer research : Gann · 1994Article
- Uncoupling of growth inhibition and differentiation in dexamethasone-treated human rhabdomyosarcoma cells.British journal of cancer · 1993Article
- Altered chromosome 6 in immortal human fibroblasts.Molecular and cellular biology · 1992Article
- Structure and expression of nuclear oncogenes in multi-stage thyroid tumorigenesis.British journal of cancer · 1989Article
- Isolation of human cDNA clones of myb-related genes, A-myb and B-myb.Nucleic acids research · 1988Article
- The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway.Molecular and cellular biology · 1988Article
- Regulation of human T-lymphocyte gene expression by interleukin 2: immediate-response genes include the proto-oncogene c-myb.Molecular and cellular biology · 1987Article
- Diltiazem inhibits transferrin receptor expression and causes G1 arrest in normal and neoplastic T cells.Molecular and cellular biology · 1986Article
- Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Structural organization and nucleotide sequence of mouse c-myb oncogene: activation in ABPL tumors is due to viral integration in an intron which results in the deletion of the 5' coding sequences.Nucleic acids research · 1986Article
- Antibodies to the evolutionarily conserved amino-terminal region of the v-myb-encoded protein detect the c-myb protein in widely divergent metazoan species.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Expression of cellular oncogenes in primary cells from human acute leukemias.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Two modes of c-myb activation in virus-induced mouse myeloid tumors.Molecular and cellular biology · 1986Article
- Activation of c-myb expression by phytohemagglutinin stimulation in normal human T lymphocytes.Molecular and cellular biology · 1985Article
- Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 1984Article
- Expression of abl and other oncogenes is independent of metastatic potential in Abelson virus-transformed malignant murine large cell lymphoma.Clinical & experimental metastasisArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophage libraries of human DNA were screened for sequences homologous to the transforming gene (v-myb) of avian myeloblastosis virus. The three overlapping clones isolated were shown to contain a total of 1.0 kilobase pair (kbp) of sequence related to v-myb distributed over 6.2 kbp. Restriction enzyme mapping and heteroduplex analysis revealed the presence of five myb-related domains interrupted by four stretches of non-homology. To study the extent of human DNA coding sequences that constitute the myb gene homologue, c-myb (human), probes spanning about 30 kbp were prepared from the clones and used to study transcription in a human hematopoietic cell line (MOLT-4). Each of the probes hybridized a 4.5-kilobase transcript, which suggests that either the c-myb (human) gene encompasses 30 kbp or it contains two or more transcription units that each give rise to a mRNA of 4.5 kilobases.
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