ArticleThe Journal of cell biology1984
Insulin-induced formation of ruffling membranes of KB cells and its correlation with enhancement of amino acid transport.
Article in The Journal of cell biology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 88 citations in OpenAlex.
- Insulin-induced endothelial cell cortical actin filament remodeling: a requirement for trans-endothelial insulin transport.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Insulin enhances L-dopa renal proximal tubule uptake: a regulatory mechanism impaired in insulin resistance.Pflugers Archiv : European journal of physiology · 2004Article
- Comparative study of protein tyrosine phosphatase-epsilon isoforms: membrane localization confers specificity in cellular signalling.The Biochemical journal · 2001Article
- bFGF and aFGF induce membrane ruffling in breast cancer cells but not in normal breast epithelial cells: FGFR-4 involvement.The Biochemical journal · 1995Article
- Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.The EMBO journal · 1994Article
- rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.Molecular and cellular biology · 1994Article
- Production of a unique antibody specific for membrane ruffles and its use to characterize the behavior of two distinct types of ruffles.The Journal of cell biology · 1993Article
- Morphological changes in Krebs II ascites tumour cells induced by insulin are associated with differences in protein composition and altered amounts of free, cytoskeletal-bound and membrane-bound polysomes.Molecular and cellular biochemistry · 1992Article
- The role of cell swelling in the stimulation of glycogen synthesis by insulin.The Biochemical journal · 1992Article
- Differential sensitivity of insulin- and adaptive-regulation-induced system A activation to microtubular function in skeletal muscle.The Biochemical journal · 1992Article
- Glioma-derived PDGF-related protein presents as 17 kd intracellularly and assembled form induces actin reorganization.Journal of neuro-oncology · 1991Article
- Insulin induces changes in the subcellular distribution of actin and 5'-nucleotidase.Molecular and cellular biochemistry · 1991Article
- Cholera toxin inhibits signal transduction by several mitogens and the in vitro growth of human small-cell lung cancer.The Journal of clinical investigation · 1990Article
- Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway.Molecular and cellular biology · 1989Article
- Fourier analysis of cell motility: correlation of motility with metastatic potential.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Mitogenic agents induce redistribution of transferrin receptors from internal pools to the cell surface.The Biochemical journal · 1986Article
- Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha.The Journal of cell biology · 1986Article
- An agent or agents produced by virus-transformed cells cause unregulated ruffling in untransformed cells.The Journal of cell biology · 1986Article
- Membrane and cytoskeletal changes associated with IgE-mediated serotonin release from rat basophilic leukemia cells.The Journal of cell biology · 1985Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin induced the formation of ruffling membranes in cultured KB cells (a cell strain derived from human epidermoid carcinoma) within 1-2 min after its addition. The ruffled regions were stained strongly with antibody to actin but not that to tubulin. Pretreatment of KB cells with agents disrupting microfilaments (cytochalasins), but not with those disrupting microtubules (colcemid, nocodazole, and colchicine) completely inhibited the formation of ruffling membranes. Pretreatment of KB cells with dibutyryl cyclic AMP, but not with dibutyryl cyclic GMP, also inhibited the formation of ruffling membranes. Addition of insulin enhanced Na+-dependent uptake of a system A amino acid (alpha-amino isobutyric acid; AIB) by the cells within 5 min after the addition, and decreased the cyclic AMP content of the cells. Treatments that inhibited insulin-induced formation of ruffling membranes of KB cells also inhibited insulin-induced enhancement of their AIB uptake. From these observations, the mechanism of insulin-induced formation of ruffling membranes and its close correlation with AIB transport are discussed.
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