ArticleBlut1983
The effect of eosinophil chemotactic factors on in vitro eosinopoiesis in the guinea pig.
Article in Blut, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 8 citations in OpenAlex.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influx of eosinophils to tissue sites is regulated by several well-characterized eosinophil chemotactic factors. In the present investigation the effect of such factors on eosinopoiesis was studied in guinea pig liquid bone marrow cultures. Addition of neutrophil-derived eosinophil chemotactic leukotrienes, synthetic leukotriene B4, zymosan-activated serum, purified hog C3a, C5a, C5a-des-arg, and synthetic N-formyl-methionyl-phenylalanine did not increase eosinophil numbers in marrow cultures, while supernatants of spleen or lymph node cells stimulated by concanavalin A were highly effective. 3H-thymidine labelling of cultured eosinophils was not increased by any of the added mediators. A quantitative correlation between eosinopoietic and eosinotactic activity could not be established. These in vitro data suggest therefore that eosinopoiesis and migration of guinea pig eosinophils to tissue sites are regulated by separate chemical mediators.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.