ArticleProceedings of the National Academy of Sciences of the United States of America1983
Recombination between antibody heavy chain variable-region genes: evidence for gene conversion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 104 citations in OpenAlex.
- The Association between Inefficient Repair of DNA Double-Strand Breaks and Common Polymorphisms of the HRR and NHEJ Repair Genes in Patients with Rheumatoid Arthritis.International journal of molecular sciences · 2024Article
- Article
- Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences.Frontiers in immunology · 2012Article
- Gene conversion in human rearranged immunoglobulin genes.Immunogenetics · 2006Article
- Immunoglobulin gene hyperconversion ongoing in chicken splenic germinal centers.The EMBO journal · 1996Article
- Structural repertoire in human VL pseudogenes of immunoglobulins: comparison with functional germline genes and amino acid sequences.Immunogenetics · 1996Article
- Evolution of V genes: DNA sequence structure of functional germline genes and pseudogenes.Immunogenetics · 1995Review
- Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.The Journal of experimental medicine · 1994Article
- A single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements.The Journal of experimental medicine · 1990Article
- Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversion.The Journal of experimental medicine · 1990Article
- Analysis of a novel VHS107 haplotype in CLA-2 and WSA mice. Evidence for gene conversion among IgVH genes in outbred populations.The Journal of experimental medicine · 1989Article
- Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.The Journal of experimental medicine · 1989Article
- Evidence for two pathways of meiotic intrachromosomal recombination in yeast.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Alternative V kappa gene rearrangements in a murine B cell lymphoma. An explantation for idiotypic heterogeneity.The Journal of experimental medicine · 1988Article
- Interaction and sequence diversity among T15 VH genes in CBA/J mice.The Journal of experimental medicine · 1988Article
- Gene conversions can generate sequence variants in the late chorion multigene families of Bombyx mori.Genetics · 1988Article
- Antibody engineering for the analysis of affinity maturation of an anti-hapten response.The EMBO journal · 1988Article
- Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences.Nucleic acids research · 1988Article
- Mutation in the CYP21B gene (Ile-172----Asn) causes steroid 21-hydroxylase deficiency.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.The Journal of experimental medicine · 1988Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The murine hybridoma line B1-8.delta 1 secretes monoclonal IgD lambda 1 antibodies specific for the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP). The variable (V) region of these antibodies is defined by a characteristic pattern of idiotopes. A spontaneous V-region variant (B1-8.V1) with altered idiotope pattern was selected. The structural variation is confined to the V region of the heavy chain. It was shown previously that the variant V region is encoded by a gene that was generated by a crossover between the rearranged VDJ gene of the wild type (B1-8.delta 1) and a neighboring germ-line VH gene. In the present study the nucleotide sequence of coding and flanking regions of the VH gene expressed in variant B1-8.V1 was determined. Wild-type and variant VH genes differ at 15 positions in a region between leader sequence and codon 66. The sequence of the region carrying the substitutions is identical to the sequence of the corresponding region in a neighboring germ-line VH gene. This implies that the variant VH gene was generated by a mechanism of recombination more complicated than single crossover. Gene conversion as the mechanism of the recombination is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.