Evidence map›Paper›PMID 6297228›Full record

ArticleActa neuropathologica1982

An immunocytochemical study of intraneuronal inclusions of the caudate and substantia nigra. Reaction with an anti-actin antiserum.

J E Goldman, D S Horoupian

Abstract read
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In one paragraph

Article in Acta neuropathologica, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

J E Goldman
D S Horoupian

Funding

CELLULAR&BIOCHEMICAL STUDIES CENTRAL NERVOUS SYSTEM GLIAR01NS017125 · NINDS · YESHIVA UNIVERSITY · PI GOLDMAN, JAMES · 1985 to 2009
$3.4M
NINDS NIH HHS NS 00524NINDS NIH HHS NS 17125
6 · The paper itself

Abstract

The composition of the eosinophilic inclusions of the large neurons in the human caudate nucleus and of neurons in the substantia nigra was investigated by immunocytochemical methods. Sections of caudate nucleus and substantia nigra were stained using a peroxidase-anti-peroxidase method with antisera to actin, to neurofilament proteins, and to a crude CNS microtubule fraction, the last of which reacts with neurofibrillary tangles. Of the several antisera, only the anti-actin antiserum gave positive results, indicating that these inclusions, composed of regularly arranged filaments, are highly ordered aggregates of actin polymers.

Indexed as

ActinsCaudate NucleusCytoskeletonHumansImmunoenzyme TechniquesInclusion BodiesMicrotubulesNeurofibrilsNeuronsSubstantia NigraActins

Identifiers

PMID6297228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.