ArticleProceedings of the National Academy of Sciences of the United States of America1982
Sarcomeric myosin heavy chain is coded by a highly conserved multigene family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 146 citations in OpenAlex.
- Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch.Journal of anatomy · 1997Article
- A myosin family reunion.Journal of muscle research and cell motility · 1996Review
- Concerted evolution of mammalian cardiac myosin heavy chain genes.Journal of molecular evolution · 1995Article
- Scallop striated and smooth muscle myosin heavy-chain isoforms are produced by alternative RNA splicing from a single gene.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- The evolutionary relationship of avian and mammalian myosin heavy-chain genes.Journal of molecular evolution · 1993Article
- Heterogeneity and distribution of fast myosin heavy chains in some adult vertebrate skeletal muscles.Histochemistry · 1992Article
- Neonatal and adult myosin heavy chains form homodimers during avian skeletal muscle development.The Journal of cell biology · 1991Article
- Assembly of avian skeletal muscle myosins: evidence that homodimers of the heavy chain subunit are the thermodynamically stable form.The Journal of cell biology · 1991Article
- Chicken nonmuscle myosin heavy chains: differential expression of two mRNAs and evidence for two different polypeptides.The Journal of cell biology · 1991Article
- Multiple polyadenylation signals and 3' untranslated sequences are conserved between chicken and human cellular myosin II transcripts.Gene expression · 1991Article
- The expression of myosin genes in developing skeletal muscle in the mouse embryo.The Journal of cell biology · 1990Article
- Myosin heavy and light chain expression during human skeletal muscle development and precocious muscle maturation induced by thyroid hormone.Anatomy and embryology · 1990Article
- Regulation of myosin heavy-chain gene expression during skeletal-muscle hypertrophy.The Biochemical journal · 1989Article
- Distribution of fast myosin heavy chain isoforms in thick filaments of developing chicken pectoral muscle.The Journal of cell biology · 1989Article
- Isolation and characterization of the complete human beta-myosin heavy chain gene.Human genetics · 1989Article
- The expression of slow myosin during mammalian somitogenesis and limb bud differentiation.The Journal of cell biology · 1988Article
- The Drosophila melanogaster tropomyosin II gene produces multiple proteins by use of alternative tissue-specific promoters and alternative splicing.Molecular and cellular biology · 1988Article
- A highly conserved mouse gene with a propensity to form pseudogenes in mammals.Molecular and cellular biology · 1988Article
- Changes in the distribution of slow skeletal myosin heavy chain SM1 in developing avian muscle fibres.Journal of muscle research and cell motility · 1988Article
- Characterization of a mammalian smooth muscle myosin heavy chain cDNA clone and its expression in various smooth muscle types.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
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4 authors at 1 institution in 1 country.
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Abstract
pMHC25, a recombinant plasmid containing myosin heavy chain (MHC) cDNA sequences from differentiated myotubes of the L6E9 rat cell line, has been shown to hybridize to all sarcomeric MHC mRNAs so far tested but not to nonsarcomeric MHC mRNAs. In addition, pMHC25 hybridizes to multiple restriction endonuclease-digested fragments of rat genomic DNA corresponding to different MHC genomic sequences. Thus, the MHC gene represented by pMHC25 is a member of a sarcomeric MHC multigene family that has regions of sequence homology shared among its members. This sarcomeric MHC multigene family has been estimated to be composed of a minimum of seven genes, some of which are polymorphic in the rat. We have also determined that pMHC25 hybridizes to MHC gene sequences in genomic DNA of all species that have striated muscle, ranging from nematodes to man. Sarcomeric MHC genes, therefore, have been horizontally and vertically conserved in evolution. Additionally, we have used the pMHC25 plasmid to demonstrate that MHC genes do not undergo rearrangement or amplification during muscle cell differentiation.
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