ArticleInfection and immunity1982
Oxidant-mediated damage of Leishmania donovani promastigotes.
Article in Infection and immunity, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- The Possible Role of Selected Vitamins and Minerals in the Therapeutic Outcomes of Leishmaniasis.Biological trace element research · 2023Review
- Adaptive responses to purine starvation in Leishmania donovani.Molecular microbiology · 2010Article
- Leishmania pifanoi amastigotes avoid macrophage production of superoxide by inducing heme degradation.Infection and immunity · 2005Article
- Excretory-secretory product of Paragonimus westermani newly excysted metacercariae inhibits superoxide production of granulocytes stimulated with IgG.The Korean journal of parasitology · 2000Article
- Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Macrophage activation by polymeric nanoparticles of polyalkylcyanoacrylates: activity against intracellular Leishmania donovani associated with hydrogen peroxide production.Pharmaceutical research · 1992Article
- Antileishmanial activity of chlorpromazine.Antimicrobial agents and chemotherapy · 1984Article
- Killing of human malaria parasites by macrophage secretory products.Infection and immunity · 1984Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Dissemination of Leishmania within the host is related to parasites undergoing unchecked proliferation. We therefore studied the effects of oxidant generating systems on promastigote multiplication by (i) direct determinations of organism proliferation and (ii) the incorporation of [3H]uracil into promastigote nucleoprotein. These two parameters correlated closely as measures of organism replication as demonstrated by parallel suppression of them by the protein synthesis inhibitors puromycin and cycloheximide and the nucleic acid synthesis inhibitors actinomycin D and mitomycin C. Promastigotes showed dose-related susceptibility to reagent and generated hydrogen peroxide (H2O2) as reflected in quantitatively similar decreases in multiplication and [3H]uracil incorporation. These effects were specific for H2O2 as catalase abrogated the dimunition in multiplication. The generation of superoxide anion by acetaldehyde-xanthine oxidase (10 mU/ml) did not alter promastigote replication or nucleoprotein synthesis. These results indicate that Leishmania donovani promastigotes are damaged by H2O2 and that the incorporation of [3H]uracil into promastigote nucleoprotein may be useful for studying the interaction of this parasite with host effector cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.