Evidence map›Paper›PMID 6265916›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1981

Molecular cloning of two fast myosin heavy chain cDNAs from chicken embryo skeletal muscle.

P K Umeda, A M Sinha, S Jakovcic, S Merten, H J Hsu, K N Subramanian, R Zak, M Rabinowitz

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1981. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 59 citations in OpenAlex.

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  9. Denervated skeletal muscle displays discoordinate regulation for the synthesis of several myofibrillar proteins.Proceedings of the National Academy of Sciences of the United States of America · 1984
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  14. Sarcomeric myosin heavy chain is coded by a highly conserved multigene family.Proceedings of the National Academy of Sciences of the United States of America · 1982
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

P K Umeda
A M Sinha
S Jakovcic
S Merten
H J Hsu
K N Subramanian
R Zak
M Rabinowitz
University of Illinois Urbana-Champaign · USUniversity of Chicago · USUniversity of Illinois Chicago · US

Funding

TURNOVER OF MYOSIN ISOENZYMES IN CARDIAC MUSCLEP01HL020592 · NHLBI · UNIVERSITY OF CHICAGO · PI HANCK, DOROTHY A · 1985 to 1999
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NHLBI NIH HHS HL09172NHLBI NIH HHS HL20592
6 · The paper itself

Abstract

Recombinant DNA clones containing sequences for two different types of myosin heavy chain (HC) genes from chicken embryonic skeletal muscle were constructed and analyzed. Specificity of the clones for myosin HC was demonstrated by hybrid-arrested translation, by hybridization to a 7.0-kb mRNA, and by comparison of DNA sequences with known amino acid sequences of rabbit skeletal muscle myosin HC. Restriction enzyme and electron-microscopic heteroduplex analysis showed the presence of two distinct but homologous cDNA sequences. Hybrid melting curves indicated that both types of sequences represent fast myosin HC sequences.

Indexed as

Cloning, MolecularAmino Acid SequenceAnimalsBase SequenceChick EmbryoDNA, RecombinantDNA Restriction EnzymesGenetic CodeMicroscopy, ElectronMusclesMyosinsNucleic Acid HybridizationPlasmidsProtein BiosynthesisRNA, MessengerTranscription, GeneticDNA, RecombinantDNA Restriction EnzymesMyosinsRNA, Messenger

Identifiers

PMID6265916
PMCPMC319454
OpenAlexW2020180067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.