ArticleThe EMBO journal1984
Cellular distribution of three mammalian Ca2+-binding proteins related to Torpedo calelectrin.
Article in The EMBO journal, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 85 citations in OpenAlex.
- Developmental regulation of tyrosine kinase substrate p36 (calpactin heavy chain) in rat cerebellum.Journal of molecular neuroscience : MN · 1989Article
- A 36 kDa monomeric protein and its complex with a 10 kDa protein both isolated from bovine aorta are calpactin-like proteins that differ in their Ca2+-dependent calmodulin-binding and actin-severing properties.The Biochemical journal · 1988Article
- 67 k calcimedin (67 kDa) is distinct from p67 calelectrin and lymphocyte 68 kDa Ca2+-binding protein.The Biochemical journal · 1988Article
- Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family.The EMBO journal · 1988Article
- Calcium-sensitive, lipid-binding cytoskeletal proteins of the human placental microvillar region.The Journal of cell biology · 1987Article
- The amino acid sequence of protein II and its phosphorylation site for protein kinase C; the domain structure Ca2+-modulated lipid binding proteins.The EMBO journal · 1987Article
- The tyrosine phosphorylation substrate p36 is developmentally regulated in embryonic avian limb and is induced in cell culture.The Journal of cell biology · 1986Article
- 67 kDa calcimedin, a new Ca2+-binding protein.The Biochemical journal · 1986Article
- The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific protein kinases is related in sequence to the S-100 protein of glial cells.The EMBO journal · 1985Article
- Characterization of calcium-dependent membrane binding proteins of brain cortex.The Biochemical journal · 1985Article
- Annexin II tetramer: structure and function.Molecular and cellular biochemistryReview
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7 authors.
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Abstract
Addition of Ca2+ to post-microsomal fractions of bovine adrenal or liver produced a sedimentable complex of membrane vesicles and cytoplasmic proteins. Proteins with apparent mol. wts. 70 000, 36 000 and 32 500 were solubilized from this complex by Ca2+ chelation. The 36 000 mol. wt. protein (p36) was immunoprecipitated by an antiserum specific for pp36, a major substrate for Rous sarcoma virus src-gene tyrosine kinase. This protein was present in many mesenchymal cells and associated with membrane cytoskeleton of bovine fibroblasts in a Ca2+-dependent manner. The 70 000 and 32 500 mol. wt. proteins were widely distributed in established cell lines, but were not clearly associated with cell organelles in tissue sections, nor retained in cytoskeleton preparations. On immunoblots p36 reacted strongly with antibodies produced against the electric fish protein Torpedo calelectrin and the similar Ca2+-binding properties and subunit mol. wts. of these proteins suggests that they might be functionally related. Since Torpedo calelectrin, p70, p36 and p32.5 were bound by lipid vesicles or microsomal membranes at micromolar free Ca2+ concentrations, regulated association with intrinsic membrane components may be involved in the functions of these widespread proteins.
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