ArticleJournal of muscle research and cell motility1983
Some functional properties of nonpolymerizable and polymerizable tropomyosin.
Article in Journal of muscle research and cell motility, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 43 citations in OpenAlex.
- Arp2/3 complex and cofilin modulate binding of tropomyosin to branched actin networks.Current biology : CB · 2015Article
- Tropomodulins and tropomyosins: working as a team.Journal of muscle research and cell motility · 2013Review
- Tropomyosin isoforms and reagents.Bioarchitecture · 2011Article
- Different effects of trifluoroethanol and glycerol on the stability of tropomyosin helices and the head-to-tail complex.Biophysical journal · 2007Article
- Tropomyosin ends determine the stability and functionality of overlap and troponin T complexes.Biophysical journal · 2003Article
- Structure and interactions of the carboxyl terminus of striated muscle alpha-tropomyosin: it is important to be flexible.Biophysical journal · 2002Article
- Relationship between alternatively spliced exons and functional domains in tropomyosin.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Stoichiometry and stability of caldesmon in native thin filaments from sheep aorta smooth muscle.The Biochemical journal · 1990Article
- Three novel brain tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene through the use of alternative promoters and alternative RNA processing.Molecular and cellular biology · 1990Article
- Some functional properties of nonpolymerizable and polymerizable tropomyosin.Journal of muscle research and cell motility · 1983Article
- The effect of cytochalasin and glutaraldehyde on F-actin filaments containing muscle and non-muscle tropomyosin.Journal of muscle research and cell motility · 1983Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The binding of 125I-labelled nonpolymerizable (brain or carboxypeptidase A-treated skeletal muscle) and polymerizable (intact skeletal muscle) tropomyosin to muscle F-actin was studied by ultracentrifugation under various conditions. The amount of nonpolymerizable tropomyosin bound to F-actin both in 0.1 M KCl and in 7 mM MgCl2 was much lower than that of the polymerizable one. In the presence of MgCl2 the amount of nonpolymerizable tropomyosin bound to F-actin approached saturation level. Under these conditions, however, the amount of skeletal muscle tropomyosin bound exceeded saturation, suggesting formation of both head-to-tail polymers and side-to-side aggregates. The latter seems to be responsible for the inhibition of acto-heavy meromyosin ATPase activity which is caused by skeletal muscle tropomyosin but not by nonpolymerizable tropomyosin. Nonpolymerizable tropomyosin can substitute for the rabbit skeletal muscle tropomyosin in the regulatory system operating in skeletal muscle. Inhibition of ATPase activity of acto-heavy meromyosin by nonpolymerizable tropomyosin in the presence of troponin and the absence of calcium ions is less than that obtained with polymerizable tropomyosin. The inhibition of ATPase activity is directly correlated with the extent of binding of nonpolymerizable tropomyosin to F-actin under the conditions of the ATPase assay.
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