ArticleProceedings of the National Academy of Sciences of the United States of America1984
Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
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Who cites it
136 citing papers in PubMed, 344 citations in OpenAlex.
- From computational models of the splicing code to regulatory mechanisms and therapeutic implications.Nature reviews. Genetics · 2025Review
- Exploiting public databases of genomic variation to quantify evolutionary constraint on the branch point sequence in 30 plant and animal species.Nucleic acids research · 2023Article
- Editorial: RNA machines.Frontiers in genetics · 2023Article
- Origin, evolution, and tissue-specific functions of the porcine repetitive element 1.Genetics, selection, evolution : GSE · 2022Article
- Phylogeny and conservation of plant U2A/U2A', a core splicing component in U2 spliceosomal complex.Planta · 2021Article
- Systematic characterization of the branch point binding protein, splicing factor 1, gene family in plant development and stress responses.BMC plant biology · 2020Article
- Structural and functional modularity of the U2 snRNP in pre-mRNA splicing.Critical reviews in biochemistry and molecular biology · 2019Review
- Article
- Identification and Functional Characterization of Two Intronic NIPBL Mutations in Two Patients with Cornelia de Lange Syndrome.BioMed research international · 2016Article
- Identification of CTLA2A, DEFB29, WFDC15B, SERPINA1F and MUP19 as Novel Tissue-Specific Secretory Factors in Mouse.PloS one · 2015Article
- Whole Exome Sequencing Reveals Novel PHEX Splice Site Mutations in Patients with Hypophosphatemic Rickets.PloS one · 2015Article
- Impact of base pair identity 5' to the spliceosomal branch site adenosine on branch site conformation.RNA (New York, N.Y.) · 2012Article
- Identification of a spliced gene from duck enteritis virus encoding a protein homologous to UL15 of herpes simplex virus 1.Virology journal · 2011Article
- Cloning and characterization of a novel alternatively spliced transcript of the human CHD7 putative helicase.BMC research notes · 2010Article
- Article
- X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.Biochemistry · 2008Article
- Transposition of two amino acids changes a promiscuous RNA binding protein into a sequence-specific RNA binding protein.RNA (New York, N.Y.) · 2008Article
- Gene structure and molecular phylogeny of the linker chains from the giant annelid hexagonal bilayer hemoglobins.Journal of molecular evolution · 2006Article
- A novel intronic cis element, ISE/ISS-3, regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence.Molecular and cellular biology · 2005Article
- Engineering the splice acceptor for improved gene expression and viral titer in an MLV-based retroviral vector.Gene therapy · 2004Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Splicing of introns of yeast pre-mRNAs requires an internal conserved sequence T-A-C-T-A-A-C that is located 20-55 nucleotides from the 3' intron boundary. Sequences differing only in certain positions from this yeast signal have now been identified in the corresponding internal region of pre-mRNA introns of a variety of animal genes. A computer program that searches for homologues to a consensus structure and calculates the accuracy of match of each homologue is used to locate these sequences. We list here the signals found by this search in introns of sea urchin, mouse, rat, and human genes and give the consensus for each species. We also give the consensus found for Drosophila and chicken and duck signals. We then discuss the accumulating evidence that these internal signals are required for splicing in animals. It is also noted that a single-stranded region of small nuclear RNA U2 contains sequences complementary both to the proposed mammalian internal signal and to the neighboring CT-A-G at the 3' intron boundary. A role for U2 ribonucleoprotein in intron splicing is thus suggested.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.