ArticleMolecular and cellular biology1984
Multiple tropomyosin polypeptides in chicken embryo fibroblasts: differential repression of transcription by Rous sarcoma virus transformation.
Article in Molecular and cellular biology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 111 citations in OpenAlex.
- Alternative splicing of the Caenorhabditis elegans lev-11 tropomyosin gene is regulated in a tissue-specific manner.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments.Molecular biology of the cell · 2015Article
- Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array.BMC genomics · 2006Article
- Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta.Oncogene · 2005Article
- A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells.Molecular biology of the cell · 2004Article
- Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation.Molecular and cellular biochemistry · 1999Review
- Transformation-related expression of a low-molecular-mass tropomyosin isoform TM5/TM30nm in transformed rat fibroblastic cell lines.Journal of cancer research and clinical oncology · 1997Article
- Transformation of Rat-1 fibroblasts with the v-src oncogene induces inositol 1,4,5-trisphosphate 3-kinase expression.The Biochemical journal · 1996Article
- Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Changes of tropomyosin isoforms during development of cross-fertilized sea urchin embryos.Development, growth & differentiation · 1996Article
- Regulation of microfilament organization and anchorage-independent growth by tropomyosin 1.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Transcriptional stimulation of the retina-specific QR1 gene upon growth arrest involves a Maf-related protein.Molecular and cellular biology · 1995Article
- Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin.The Journal of cell biology · 1994Article
- Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases.Molecular and cellular biology · 1993Article
- Transcriptional downregulation of the retina-specific QR1 gene by pp60v-src and identification of a novel v-src-responsive unit.Molecular and cellular biology · 1993Article
- Differential regulation of tropomyosin isoform organization and gene expression in response to altered actin gene expression.The Journal of cell biology · 1993Article
- Molecular cloning and characterization of a cDNA showing negative regulation in v-src-transformed 3Y1 rat fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- In vitro and in vivo characterization of four fibroblast tropomyosins produced in bacteria: TM-2, TM-3, TM-5a, and TM-5b are co-localized in interphase fibroblasts.The Journal of cell biology · 1992Article
- Regulation of the junB gene by v-src.Molecular and cellular biology · 1992Article
- Expression of v-src in embryonic neural retina alters cell adhesion, inhibits histogenesis, and prevents induction of glutamine synthetase.Molecular and cellular biology · 1991Article
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2 authors.
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Abstract
We have found that cytoskeletal extracts of cultured chicken embryo fibroblasts contain at least seven distinct polypeptides (two major and five minor) which cross-react with antiserum to chicken smooth muscle tropomyosin. These polypeptides range in apparent molecular weight from 31,000 to 47,000, and each is encoded by mRNAs which specifically hybridize to cloned muscle tropomyosin cDNAs. These nonmuscle tropomyosin species and their respective mRNAs are electrophoretically distinct from those of chicken skeletal muscle and appear by genomic DNA blotting to comprise a part of a multigene tropomyosin family. In Rous sarcoma virus-transformed chicken embryo fibroblasts, synthesis of the tropomyosins is differentially repressed such that the synthesis of the major species (cp35 and cp33, cytoskeletal proteins of molecular weight 35,000 and 33,000, respectively) and three minor species is drastically reduced, whereas the synthesis of two of the minor species (cp32 and cp31) remains essentially unchanged. Analysis of cellular mRNA and runoff nuclear transcription experiments indicate that the repression of tropomyosin synthesis by Rous sarcoma virus transformation occurs at the level of transcription. This repression of tropomyosin synthesis is partially mimicked in normal chicken embryo fibroblasts during incubation in high-NaCl medium, a condition in which chicken embryo fibroblasts acquire many characteristics of transformed cells.
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