ArticleThe Journal of cell biology1984
Expression of unusually large keratins during terminal differentiation: balance of type I and type II keratins is not disrupted.
Article in The Journal of cell biology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 40 citations in OpenAlex.
- Revisiting the significance of keratin expression in complex epithelia.Journal of cell science · 2022Article
- In Vitro Model of the Epidermis: Connecting Protein Function to 3D Structure.Methods in enzymology · 2016Review
- Sequence and expression of a type II keratin, K5, in human epidermal cells.Molecular and cellular biology · 1988Article
- Keratin filament composition of human epidermal spinous and granular cell fractions selected by flow cytometric sorting.Archives of dermatological research · 1987Article
- Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells.The Journal of cell biology · 1986Article
- Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes.Molecular and cellular biology · 1986Article
- Structure of a gene for the human epidermal 67-kDa keratin.Proceedings of the National Academy of Sciences of the United States of America · 1985Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When a basal epidermal cell undergoes a commitment to terminally differentiate, it ceases to divide and begins to migrate outward towards the surface of the skin. Dramatic changes in its cytoskeletal architecture take place, accompanied by numerous changes in the expression of keratins, a family of related polypeptides that form 8-nm filaments in these cells. We show here that a shift to the synthesis of unusually large keratins occurs that does not seem to disrupt the ratio of two distinct subfamilies of keratins. Preliminary studies indicate that this differentiation-specific shift may be at the level of transcriptional rather than post-transcriptional regulation. The striking similarities between these large keratins and the type I and type II keratins of basal epidermal cells suggests the important role that both classes of large keratin sequences must play in the assembly of the intermediate filaments within the differentiating keratinocyte.
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Registered trials
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