ArticleImmunology1984
Stage-specific antigens of Nematospiroides dubius.
Article in Immunology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Partial Protection of Goats againstVaccines · 2024Article
- Immune modulation and modulators in Heligmosomoides polygyrus infection.Experimental parasitology · 2012Review
- Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins.Journal of proteomics · 2011Article
- Gastrointestinal nematode infection exacerbates malaria-induced liver pathology.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Dealing with different methods for Kluyveromyces lactis beta-galactosidase purification.Biological procedures online · 1998Article
- Irradiated larval vaccination and antibody responses evaluated in relation to the expression of immunity to Heligmosomoides polygyrus.Parasitology research · 1996Article
- Echinococcus granulosus: the potential use of specific radiolabelled antibodies in diagnosis by immunoscintigraphy.Clinical and experimental immunology · 1990Article
- Surface antigens of Obeliscoides cuniculi inducing local and systemic humoral responses in infected rabbits.Parasitology research · 1988Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The results presented here demonstrate conclusively for the first time that Nematospiroides dubius exhibits stage specificity in the expression of cuticular antigens, and infer that the stage specific antigens demonstrable on L4 stages 6 days following infection account for the immunity generated by abbreviated infection regimes. L4 stages 6 days following infection appeared to possess a stage-specific surface molecule (MW 16,000) which either disappeared on maturity to adults or somehow became unavailable to the surface probes used in this study. A molecule of similar molecular size was recognized by sera raised in mice immunized either by the administration of irradiated larvae or by using an antihelminthic-abbreviated infection and also by sera from jirds which had recently expelled N. dubius. The immune derivation of these sera supports the hypothesis that the molecule having a MW of 16,000 is functionally immunogenic. A monoclonal antibody (29-1-D1) was used to demonstrate a further stage specific molecule (MW 65,000), this time on the surface of adult N. dubius. The application of biochemical techniques suggested that further heterogeneity existed in surface molecules resolving between 60,000-70,000 on SDS-PAGE and a hypothesis was formulated in an attempt to explain this phenomenon.
Indexed as
Identifiers
6208145PMC1454832What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.