ArticleNucleic acids research1984
Evidence for transcriptional regulation of the myosin heavy chain gene during myogenesis.
Article in Nucleic acids research, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- The SUV39 Family of H3K9 Methyltransferases in Skeletal Muscle Stem Cells.FASEB bioAdvances · 2025Review
- Bioactive nanoglass regulating the myogenic differentiation and skeletal muscle regeneration.Regenerative biomaterials · 2023Article
- Structural alterations in chromatin during myogenesis in the chicken.Molecular and cellular biochemistry · 1988Article
- A long polypyrimidine/polypurine tract induces an altered DNA conformation on the 3' coding region of the adjacent myosin heavy chain gene.Nucleic acids research · 1987Article
- Functional effects of CRP binding to nuclei.Immunology · 1986Article
- Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature.The Journal of cell biology · 1985Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the changes accompanying skeletal muscle cell (myoblast) fusion is a dramatic increase in synthesis of muscle specific proteins, one of which is myosin. The underlying mechanism for this burst in synthesis is not yet understood but may occur by two mechanisms: (a) gradual storage of mRNA and translational control as found by others or (b) gene activation and rapid synthesis of mRNA for immediate translation. In this paper we show that the myosin gene changes its organization such that postfusion skeletal muscle cells show an increased susceptibility to DNase I, a recognized probe for gene activation. We also show that this change accompanies an increase in rate of transcription and an increased cell content of myosin heavy chain mRNA. This work shows that transcriptional control is an important mechanism during muscle cell development in addition to the translational control shown by other workers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.