ArticleThe American journal of pathology1983
Experimental cholestasis promotes the deposition of glomerular IgA immune complexes.
Article in The American journal of pathology, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 42 citations in OpenAlex.
- The Role of Inflammation in Cholestatic Liver Injury.Journal of inflammation research · 2023Review
- IgA nephropathy: clearance kinetics of IgA-containing immune complexes.Seminars in immunopathology · 2018Review
- Experimental IgA nephropathy: factors influencing IgA-immune complex deposition in the glomerulus.Springer seminars in immunopathology · 1994Review
- Immunopathogenesis of experimental IgA nephropathy.Springer seminars in immunopathology · 1994Review
- Defense system in the biliary tract against bacterial infection.Digestive diseases and sciences · 1992Review
- IgA nephropathy in a child with human immunodeficiency virus type 1 infection.Pediatric nephrology (Berlin, Germany) · 1991Article
- Detection and characterization of circulating and glomerular immune complexes in experimental IgA nephropathy.Immunology · 1990Article
- Comparative studies on immunoglobulins, complement component (C3), albumin, and immunoglobulin A-containing circulating immune complexes in serum and bile of patients with biliary obstruction.Digestive diseases and sciences · 1988Article
- IgA containing circulating immune complexes and IgA anti-single stranded DNA antibodies in patients with obstructive jaundice.Clinical and experimental immunology · 1985Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Previous experimental and clinical studies support a role for the hepatobiliary system in the clearance of oligomeric IgA from serum, and alterations of this system have been associated with the deposition of IgA in the renal mesangium. The present studies in mice address the question of whether the mesangial deposition of IgA following cholestasis includes immune complexes. While bile duct ligation resulted in mesangial IgA deposition within several days in approximately 75% of animals, whether deliberately orally immunized, nonimmunized, or given injected immune complexes, mice that underwent sham operations had IgA deposits only if orally immunized. Moreover, mice that had been orally immunized or given injected immune complexes and whose bile ducts had been ligated contained deposits of specific IgA antibody and antigen. In the ligated mice some of the IgA was secretory IgA, as demonstrated by the presence of secretory component. Thus, bile duct ligation promotes the deposition of circulating IgA immune complexes, presumably by decreasing their clearance from serum, and gives rise to secretory IgA in the glomerular mesangium. The secretory immune system probably plays a role in the pathogenesis of idiopathic and cirrhosis-related human IgA nephropathy.
Indexed as
Identifiers
6194689PMC1916307W1524652166What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.