ArticleResearch in veterinary science1983
In vitro effects of lipopolysaccharides and mycobacterial cell wall components on swine alveolar macrophages.
Article in Research in veterinary science, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- The activity of milk leukocytes in response to a water-soluble fraction of Mycobacterium phlei in bovine subclinical mastitis.Veterinary research communications · 2004Article
- Modulatory effect of mycobacterium cell wall extract (Regressin) on lymphocyte blastogenic activity and macrophage cytokine gene transcription in swine.Clinical and diagnostic laboratory immunology · 1997Article
- Recombinant porcine interferon-gamma activates in vitro porcine adherent mononuclear cells to produce interleukin 1.Veterinary immunology and immunopathology · 1990Article
- Activated porcine alveolar macrophages: are biological response modifiers the answer?Veterinary immunology and immunopathology · 1989Article
- Immune responses to the lipopolysaccharides and capsular polysaccharides of Haemophilus pleuropneumoniae in convalescent and immunized pigs.Infection and immunity · 1986Article
- Effects of immunopotentiating agents on alveolar macrophage properties.Comparative immunology, microbiology and infectious diseases · 1986Review
- [Swine alveolar macrophages: a review].Comparative immunology, microbiology and infectious diseases · 1985Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The possible activation of swine alveolar macrophages (AM) by lipopolysaccharides (LPS) and mycobacterial cell wall components such as muramyl dipeptide (MDP) and interphase material (IPM) was investigated. Swine AM were harvested by post mortem lung washings and the following functions were assayed: adherence and spreading in cultures; phagocytosis of 51Cr-labelled chicken red cells; cytostatic activity against xenogeneic tumour cells (P815 mastocytoma cells); monokine synthesis; interferon and LAF (lymphocyte activating factor or interleukin-1). Incubation of swine AM with either MDP, LPS or IPM (0.1 micrograms to 100 micrograms/ml) for 24 hours did not affect the cell viability but increased their adherence and spreading slightly. Phagocytosis was not markedly modified. Under the same experimental conditions, the unstimulated AM cultures exhibited a strong cytostatic activity which was not modified by these components. No interferon synthesis could be observed in the normal or stimulated AM cultures. In contrast, LAF activity was consistently increased after 48 hours of incubation with LPS, whereas MDP produced this effect only in some experiments.
Indexed as
Identifiers
6190207PMC7125692W2405206470What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.