ArticleThe Journal of clinical investigation1983
Involvement of immunoglobulin E in the secretory processes of alveolar macrophages from asthmatic patients.
Article in The Journal of clinical investigation, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 239 citations in OpenAlex.
- Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study.Respiratory research · 2012Trial
- Harnessing the Anti-Tumor Mediators in Mast Cells as a New Strategy for Adoptive Cell Transfer for Cancer.Frontiers in oncology · 2022Review
- An in vitro alveolar macrophage assay for predicting the short-term inhalation toxicity of nanomaterials.Journal of nanobiotechnology · 2016Article
- Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo.Free radical biology & medicine · 2011Article
- FcgammaRIIb inhibits allergic lung inflammation in a murine model of allergic asthma.PloS one · 2010Article
- The role of immunoglobulin E and immune inflammation: implications in allergic rhinitis.Current allergy and asthma reports · 2005Review
- Autologously up-regulated Fc receptor expression and action in airway smooth muscle mediates its altered responsiveness in the atopic asthmatic sensitized state.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Cell surface antigen expression by peripheral blood monocytes in allergic asthma: results of 2.5 years therapy with inhaled beclomethasone dipropionate.Mediators of inflammation · 1996Article
- Nasal hyperreactivity and inflammation in allergic rhinitis.Mediators of inflammation · 1996Article
- Release of monokines by pulmonary macrophages following antigen challenge in sensitized guinea pigs.Inflammation · 1994Article
- Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals.The Journal of experimental medicine · 1994Article
- Modulation of adhesion molecule expression on endothelial cells during the late asthmatic reaction: role of macrophage-derived tumour necrosis factor-alpha.Clinical and experimental immunology · 1993Article
- Protein tyrosine kinase but not protein kinase C inhibition blocks receptor induced alveolar macrophage activation.Mediators of inflammation · 1993Article
- Prostaglandin cyclooxygenase products but not thromboxane A(2) are involved in the pathogenesis of ewthromelalgia in thrombocythaemia.Mediators of inflammation · 1993Article
- Enhanced responsiveness of ovalbumin-sensitized guinea-pig alveolar macrophages to tachykinins.British journal of pharmacology · 1992Article
- Two forms of the low-affinity Fc receptor for IgE differentially mediate endocytosis and phagocytosis: identification of the critical cytoplasmic domains.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Expression, regulation and function of human Fc epsilon RII (CD23) antigen.Immunologic research · 1992Review
- IgE-dependent activation of alveolar macrophages augments neurally mediated contraction of small airways.British journal of pharmacology · 1991Article
- Effect of IgE-stimulated alveolar macrophages on tracheal epithelial bioelectric properties in dogs.Lung · 1991Article
- Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveolar macrophages from nonatopic donors were passively sensitized with allergen-specific IgE antibody from the serum of asthmatic patients. A selective release of 4-8% of the lysosomal beta-glucuronidase of these cells occurred within 30 min of contact with the related allergen or with anti-human IgE antibody, in the absence of any mast or basophil cells. The cell reactivity was dependent on the interaction of macrophages with IgE, as shown by the disappearance of the allergen-induced enzyme release after heating or IgE-immune adsorption of the sensitizing serum, but not after IgG-adsorption. Alveolar macrophages from asthmatic patients behaved similarly to passively sensitized normal macrophages. Contact with the related allergen or with anti-IgE antibody induced the same percentage of enzyme release, demonstrating that these cells possess allergen-specific IgE bound on their surface. 18% of them formed rosettes with anti-IgE-coated sheep erythrocytes, and 15-22% with allergen-coated erythrocytes, but lost this property after preincubation with the specific allergen. The presence of IgE-specific receptors on the macrophage surface was demonstrated both at the ultrastructural level with immunoperoxidase labeling, and at low magnification by the formation of 15-18% rosettes with human IgE-coated erythrocytes. The formation of such rosettes was inhibited after incubation of alveolar phagocytes with aggregated myeloma IgE. On the basis of these observations, the participation of the alveolar macrophages in IgE-mediated pulmonary hypersensitivity must be considered. Its precise involvement requires, however, further investigations.
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