ArticleImmunology1983
Restricted sets of parasite antigens from the surface of different stages and sexes of the nematode parasite Nippostrongylus brasiliensis.
Article in Immunology, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Immunity to Soil-Transmitted Helminths: Evidence From the Field and Laboratory Models.Frontiers in immunology · 2020Review
- Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites.Genome biology · 2004Article
- Modulation of B-cell proliferative response by a soluble extract of Nippostrongylus brasiliensis.Infection and immunity · 2000Article
- Embryonic development period and the prevalence of avian blood parasites.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- IgE antibody production in rats against multiple components of excretory-secretory products of the nematode Nippostrongylus brasiliensis.Immunology · 1991Article
- Surface antigens of Obeliscoides cuniculi inducing local and systemic humoral responses in infected rabbits.Parasitology research · 1988Article
- Homology and heterology between the secreted antigens of the parasitic larval stages of Ascaris lumbricoides and Ascaris suum.Clinical and experimental immunology · 1987Article
- Stage-specific secreted antigens of the parasitic larval stages of the nematode Ascaris.Immunology · 1986Article
- Characterization of antigens of the nematode Nippostrongylus brasiliensis by monoclonal antibodies.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1985Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface molecules of parasitic stages of the nematode Nippostrongylus brasiliensis can be readily iodinated by the chloramine T technique, and assessed for antigenic reactivity with humoral antibody from infected animals. Free-living infective larvae are less amenable to analysis by this, or similar methods, but within 18 hr of larvae entering the host, new macromolecular surface antigens can be detected. The parasites change their surface antigens twice more in the course of the maturation to the adult stage. Surface antigens are stage-specific: lung larvae (L3), intestinal larvae (L4) and gut-living adults each possess characteristic sets of cuticular molecules. Single stage infections result in antibody reactive only to the antigens from the homologous stage. The adult surface appears to bear the greatest number of antigens, one of which is found only on the male worm. The composition of these antigens does not differ grossly between adult worms from a naive or immune host, or worms established after the adaptation of a 'trickle' (multiple low dose) infection. There appears to be an interesting contrast between the rapidity and extent of changes in surface antigens in the early phases of infection, and the stability of adult antigens analysed at different points in the host immune response.
Indexed as
Identifiers
6184314PMC1453999What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.