ArticleProceedings of the National Academy of Sciences of the United States of America1982
Microinjection into an identified axon to study the mechanism of fast axonal transport.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- VEGF Axonal Transport Dependent on Kinesin-1B and Microtubules Dynamics.Frontiers in molecular neuroscience · 2017Article
- Bidirectional cargo transport: moving beyond tug of war.Nature reviews. Molecular cell biology · 2014Review
- Formation of microtubule-based traps controls the sorting and concentration of vesicles to restricted sites of regenerating neurons after axotomy.The Journal of cell biology · 2007Article
- The axonal transport of mitochondria.Journal of cell science · 2005Review
- Glutamate and amyloid beta-protein rapidly inhibit fast axonal transport in cultured rat hippocampal neurons by different mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport.Molecular biology of the cell · 1999Article
- Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons.The Journal of cell biology · 1995Article
- Axoplasmic transport of horseradish peroxidase in single neurons of the dorsal root ganglion studied in vitro by microinjection.Cell and tissue research · 1992Article
- Identification of a MAP 2-like ATP-binding protein associated with axoplasmic vesicles that translocate on isolated microtubules.The Journal of cell biology · 1986Article
- Gliding movement of and bidirectional transport along single native microtubules from squid axoplasm: evidence for an active role of microtubules in cytoplasmic transport.The Journal of cell biology · 1985Article
- erythro-9-[3-(2-Hydroxynonyl)]adenine is an effective inhibitor of cell motility and actin assembly.Proceedings of the National Academy of Sciences of the United States of America · 1984Article
- A molecular description of nerve terminal function.Annual review of biochemistry · 1983Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Microinjection into an axon of an identified invertebrate neuron is shown to be a useful technique for analyzing the mechanisms of fast axonal transport. It permits direct assessment of the effect of agents that cannot permeate the plasma membrane on the translocation of material in the axon. The actin filament depolymerizer DNase I, when injected into the axon of the Aplysia neuron R2, caused a local block of fast transport of [3H]glycoprotein. Two agents that should interfere with the functioning of actin filaments without causing extensive depolymerization, tne N-ethylmaleimide-modified nuclease S1 fragment of myosin (injected) and dihydrocytochalasin B (applied externally). had no effect. Together these results suggest that actin plays a structural role in the axonal cytoskeleton rather than a role in transport force generation, the effect of DNase I being mediated by structural disordering of the axoplasm. Experiments were also done with inhibitors of dynein, the microtubule-associated ATPase. erythro-9-[3-(2-Hydroxynonyl)]adenine blocked transport but vanadate was ineffective.
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