ArticleProceedings of the National Academy of Sciences of the United States of America1980
Analysis of the mechanism of fast axonal transport by intracellular injection of potentially inhibitory macromolecules: evidence for a possible role of actin filaments.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Nucleotide- and Protein-Dependent Functions ofMolecular biology of the cell · 2022Article
- Synaptic vesicle traffic is supported by transient actin filaments and regulated by PKA and NO.Nature communications · 2020Article
- Glutamate and amyloid beta-protein rapidly inhibit fast axonal transport in cultured rat hippocampal neurons by different mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons.The Journal of cell biology · 1995Article
- The actin-binding protein comitin (p24) is a component of the Golgi apparatus.The Journal of cell biology · 1993Article
- The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin binding.The Biochemical journal · 1990Article
- cAMP-mediated inhibition of intracellular particle movement and actin reorganization in Dictyostelium.The Journal of cell biology · 1989Article
- Probing the role of nonmuscle tropomyosin isoforms in intracellular granule movement by microinjection of monoclonal antibodies.The Journal of cell biology · 1989Article
- Two classes of actin microfilaments are associated with the inner cytoskeleton of axons.The Journal of cell biology · 1988Article
- Gliding movement of and bidirectional transport along single native microtubules from squid axoplasm: evidence for an active role of microtubules in cytoplasmic transport.The Journal of cell biology · 1985Article
- Interaction of actin filaments with microtubules.The Journal of cell biology · 1984Article
- Analysis of the role of microtubules and actin in erythrophore intracellular motility.The Journal of cell biology · 1983Article
- A molecular description of nerve terminal function.Annual review of biochemistry · 1983Review
- Microinjection into an identified axon to study the mechanism of fast axonal transport.Proceedings of the National Academy of Sciences of the United States of America · 1982Article
- Effects of exogenous proteins on cytoplasmic streaming in perfused Chara cells.The Journal of cell biology · 1982Article
- High voltage electron microscopy studies of axoplasmic transport in neurons: a possible regulatory role for divalent cations.The Journal of cell biology · 1982Article
- Actin filament capping protein from bovine brain.The EMBO journal · 1982Article
- Characterization of brevin, a serum protein that shortens actin filaments.Proceedings of the National Academy of Sciences of the United States of America · 1981Article
- Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 1980Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Although actin is thought to participate in several types of cell motility other than muscle contraction, no direct evidence has linked it to the force-generating mechanism for fast axonal transport. We have obtained evidence for the involvement of actin by microinjecting, into the serotonergic giant cerebral neuron of Aplysia, two preparations that have been shown to depolymerize actin filaments. One is a fraction of rabbit serum containing a heat-labile gamma globulin that affects actin polymerization in a manner similar to that of cytochalasin and several proteins that are thought to regulate the length of actin filaments. The other is bovine pancreatic DNase I which binds to actin stoichiometrically. Both preparations substantially decreased the transport of storage vesicles containing [3H]serotonin. Phalloidin, a toxic fungal peptide that binds to actin filaments but stabilizes rather than depolymerizes them, did not inhibit transport. We have not yet determined whether the inhibition od transport occurs during export of [3H]serotonin from the cell body into the axon or during translocation along the axon. Nevertheless, these observations provide a promising experimental indication that actin is involved in fast axonal transport.
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