ArticleImmunology1980
Rheumatoid factors in mice: non-specific activators of heterophile rheumatoid factor production.
Article in Immunology, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- IgG isotype and isotype specificity of murine monoclonal IgG rheumatoid factors.Clinical and experimental immunology · 1990Article
- The stimulation of IgM rheumatoid factor from human B lymphocytes by rheumatoid arthritis complement-activating immune complexes.Clinical and experimental immunology · 1988Article
- Detection and specificity of antibodies secreted by spleen cells in mice immunized with Streptococcus mutans.Infection and immunity · 1986Article
- Simultaneous induction of rheumatoid factor- and antigen-specific antibody-secreting cells during the secondary immune response in man.Clinical and experimental immunology · 1985Article
- Article
- Immune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice.The Journal of experimental medicine · 1985Article
- Detection of IgG rheumatoid factor secreting cells in autoimmune MRL/1 mice: a kinetic study.Clinical and experimental immunology · 1984Article
- Article
- Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response.The Journal of experimental medicine · 1983Article
- Pretreatment of mice with anti-IgD serum does not result in suppression of immune responsiveness induced by TNP-AECM-Ficoll or lipopolysaccharide.Immunology · 1983Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although possibly the best, LPS is by no means the only non-specific activator of immune responsiveness (AIr). Plant lectins such as PHA and PWM have some ability to stimulate both total IgM production (reverse IgM PFC) and more particularly heterophile and homophile IgM rheumatoid factor (RF) responses, together with IgM 'antibody' responses to target antigens such as xenogeneic red blood cells or haptens such as TNP. Some parasitic infections and/or parasite antigens were shown to be powerful non-specific AIr, while the injection of dextran sulphate was shown to lead to a great increase in spleen cellularity and total IgM (reverse) PFC but failed to stimulate a heterophile (BIG) RF PFC response.
Indexed as
Identifiers
6161873PMC1458143W2399512042What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.