ArticleThe Journal of cell biology1980
Cytoskeleton of human platelets at rest and after spreading.
Article in The Journal of cell biology, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- TUBA4A: The Tale of an Unconventional Tubulin.Cytoskeleton (Hoboken, N.J.) · 2026Review
- A circle of life: platelet and megakaryocyte cytoskeleton dynamics in health and disease.Open biology · 2024Review
- Use of electron microscopy to study platelets and thrombi.Platelets · 2020Review
- Platelet and endothelial adhesion on fluorosurfactant polymers designed for vascular graft modification.Journal of biomedical materials research. Part A · 2009Article
- Article
- beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Platelet adhesion: structural and functional diversity of short dystrophin and utrophins in the formation of dystrophin-associated-protein complexes related to actin dynamics.Thrombosis and haemostasis · 2005Article
- Article
- Actin dynamics in platelets.International review of cytology · 2002Review
- Inhibition of cytoskeletal assembly by cytochalasin B prevents signaling through tyrosine phosphorylation and secretion triggered by collagen but not by thrombin.The American journal of pathology · 2002Article
- Cytoskeletal domains in the activated platelet.Cell motility and the cytoskeleton · 1995Article
- Granula motion and membrane spreading during activation of human platelets imaged by atomic force microscopy.Biophysical journal · 1994Article
- Modulation of the interaction between G-actin and thymosin beta 4 by the ATP/ADP ratio: possible implication in the regulation of actin dynamics.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets.The Journal of cell biology · 1993Article
- Mechanisms of actin rearrangements mediating platelet activation.The Journal of cell biology · 1992Article
- Dynamic redistribution of major platelet surface receptors after contact-induced platelet activation and spreading. An immunoelectron microscopy study.The American journal of pathology · 1992Article
- Formation and contraction of a microfilamentous shell in saponin-permeabilized platelets.The Journal of cell biology · 1991Article
- The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments.The Journal of cell biology · 1991Article
- Morphological evidence for the association of plasma membrane glycoprotein IIb/IIIa with the membrane skeleton in human platelets.Histochemistry · 1991Article
- Separate and combined interactions of fibrinogen-gold and latex with surface-activated platelets.The American journal of pathology · 1990Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The fine structure of resting and activated platelets was compared using two approaches novel to this dense cytoplasm. First, rapid lysis of platelets on carbon-coated grids was following by negative staining of the "cytoskeleton." Second, a brief, minimal fixation of platelets in plasma was coupled with partial lysis and examination of the unstained whole mounts at 200 kV. The results showed that the dense ground cytoplasm of discoid, fully resting platelets appeared granular or amorphous, and microfilaments were not observed. A coiled microtubule terminated in one, free, straight end. When any slight degree of activation occurred, microfilaments could be detected in the platelets. In fully spread specimens, the amorphous character of the resting cytoplasm was strikingly altered into an interconnected network of microfilaments. Stereo views of the whole mounts showed that dense granules, 100-250 nm in diameter, appeared as if suspended in the filament nets. The results support the view that platelet activation involves a major assembly of microfilaments from amorphous precursors. The change can only be seen convincingly when stringent precautions are taken during preparation because the platelets are very easily activated by thermal or mechanical stimuli.
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