ArticleThe Journal of cell biology1984
Inhibition of neurite initiation and growth by taxol.
Article in The Journal of cell biology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 194 citations in OpenAlex.
- Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).The pharmacogenomics journal · 2014Trial
- Chemotherapy-induced peripheral neuropathy in patients with breast cancer treated with taxanes (Review).Oncology letters · 2025Review
- Arginylation of ⍺-tubulin at E77 regulates microtubule dynamics via MAP1S.The Journal of cell biology · 2025Article
- Insights on the Role of α- and β-Tubulin Isotypes in Early Brain Development.Molecular neurobiology · 2023Review
- Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo.EMBO reports · 2022Article
- Towards a comprehensive approach for characterizing cell activity in bright-field microscopic images.Scientific reports · 2022Article
- FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin.Cellular and molecular life sciences : CMLS · 2022Article
- SUMOylation of α-tubulin is a novel modification regulating microtubule dynamics.Journal of molecular cell biology · 2021Article
- Dynein-mediated microtubule translocation powering neurite outgrowth in chick andJournal of cell science · 2020Article
- Chemotherapy-Induced Peripheral Neuropathy and Changes in Cytoskeleton.International journal of molecular sciences · 2019Review
- Role of Spinal Cord αFrontiers in neuroscience · 2019Article
- Modeling the Axon as an Active Partner with the Growth Cone in Axonal Elongation.Biophysical journal · 2018Article
- Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization.Frontiers in cellular neuroscience · 2018Article
- Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects.Experimental neurology · 2017Article
- Kif1B Interacts with KBP to Promote Axon Elongation by Localizing a Microtubule Regulator to Growth Cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons.Experimental neurology · 2016Article
- Hippocampal Hyperexcitability is Modulated by Microtubule-Active Agent: Evidence from In Vivo and In Vitro Epilepsy Models in the Rat.Frontiers in cellular neuroscience · 2016Article
- Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones.Molecular biology of the cell · 2015Article
- Cytoskeletal and signaling mechanisms of neurite formation.Cell and tissue research · 2015Review
- Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We cultured sensory neurons from chick embryos in media containing the alkaloid taxol at concentrations from 7 X 10(-9) to 3.5 X 10(-6) M. When plated at taxol concentrations above 7 X 10(-8) M for 24 h, neurons have short broad extensions that do not elongate on the culture substratum. When actively growing neurites are exposed to these levels of taxol, neurite growth stops immediately and does not recommence. The broad processes of neurons cultured 24 h with taxol contain densely packed arrays of microtubules that loop back at the ends of the process. Neurofilaments are segregated from microtubules into bundles and tangled masses in these taxol-treated neurons. At the ends of neurites treated for 5 min with taxol, microtubules also turn and loop back abnormally toward the perikaryon. In the presence of 7 X 10(-9) M taxol neurites do grow, although they are broader and less branched than normally. The neurites of these cells appear to have normal structure except for a large number of microtubules. Taxol probably stimulates microtubule polymerization in these cultured neurons. At high levels of the drug, this action inhibits neurite initiation and outgrowth by removing free tubulin from the cytoplasm and destroying the normal control of microtubule assembly in growing neurites. The rapid inhibition suggests that microtubule assembly may occur at neurite tips. At lower concentrations, taxol may slightly enhance the mechanisms of microtubule assembly in neurons, and this alteration of normal processes changes the morphogenetic properties of the growing neurites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.