ArticleProceedings of the National Academy of Sciences of the United States of America1982
Coexistence in human and primate neuromuscular junctions of enzymes synthesizing acetylcholine, catecholamine, taurine, and gamma-aminobutyric acid.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 70 citations in OpenAlex.
- Adrenergic Modulation of Acetylcholine Release at the Mouse Neuromuscular Junctions of Fast-Twitch Skeletal Muscle.Neurochemical research · 2025Review
- Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction.Journal of muscle research and cell motility · 2024Review
- Sympathetic neuropathology is revealed in muscles affected by amyotrophic lateral sclerosis.Frontiers in physiology · 2023Article
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor.Frontiers in physiology · 2021Article
- GABA in developing rat skeletal muscle and motor neurons.Protoplasma · 2020Article
- Motor Endplate-Anatomical, Functional, and Molecular Concepts in the Historical Perspective.Cells · 2019Article
- The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.Acta physiologica (Oxford, England) · 2019Article
- Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle.International journal of molecular sciences · 2018Article
- Alterations of cAMP-dependent signaling in dystrophic skeletal muscle.Frontiers in physiology · 2013Review
- Article
- A subpopulation of outer hair cells possessing GABA receptors with tonotopic organization.Archives of oto-rhino-laryngology · 1989Article
- Cholinergic neurons containing GABA-like and/or glutamic acid decarboxylase-like immunoreactivities in various brain regions of the rat.Experimental brain research · 1988Article
- Evidence for parallel actions of a molluscan neuropeptide and serotonin in mediating arousal in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 1984Article
- Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.Proceedings of the National Academy of Sciences of the United States of America · 1983Article
- Synthesizing enzymes for four neuroactive substances in motor neurons and neuromuscular junctions: light and electron microscopic immunocytochemistry.Proceedings of the National Academy of Sciences of the United States of America · 1982Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Coexistence of neurotransmitter-synthesizing enzymes choline acetyltransferase, cysteine sulfinic acid decarboxylase, tyrosine hydroxylase, and L-glutamic acid decarboxylase was demonstrated at human and primate neuromuscular junctions with specific antibodies directed against these enzymes. Motor end plates were identified in unfixed cryostat sections by standard cholinergic markers for acetylcholinesterase and the acetylcholine receptor. Each of the four transmitter-synthesizing enzymes was localized at end plates displaying these markers. The presence of any two of the four enzymes at a given end plate was established by (i) showing immunoreaction for one enzyme followed by elution and demonstration of immunoreaction for a second enzyme, and (ii) paired immunofluorescence with simultaneous demonstration of one enzyme with a rhodamine-labeled second antibody and of the other enzyme with a fluorescein-labeled second antibody. These findings imply that motor nerve terminals have the capacity for synthesizing not only acetylcholine but also taurine, catecholamines, and gamma-aminobutyric acid. These substances, in turn, may participate in the normal regulation of nerve-muscle interaction or be significant in specific disorders involving the motor unit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.