ReviewCancer metastasis reviews1984
Cysteine proteinases and metastasis.
Review in Cancer metastasis reviews, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 216 citations in OpenAlex.
- Circ_0020014 mediates CTSB expression and participates in IL-1β-prompted chondrocyte injury via interacting with miR-24-3p.Journal of orthopaedic surgery and research · 2023Article
- Disintegrin-like Protein Strategy to Inhibit Aggressive Triple-Negative Breast Cancer.International journal of molecular sciences · 2023Article
- FABP7 inhibits proliferation and invasion abilities of cutaneous squamous cell carcinoma cells via the Notch signaling pathway.Oncology letters · 2022Article
- Uncovering mediators of collagen degradation in the tumor microenvironment.Matrix biology plus · 2022Article
- The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.Molecular cancer · 2018Article
- Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake.Cell reports · 2017Article
- A Proposal for the Evolution of Cathepsin and Silicatein in Sponges.Journal of molecular evolution · 2015Article
- The source of matrix-degrading enzymes in human cancer: Problems of research reproducibility and possible solutions.The Journal of cell biology · 2015Article
- Proteomic analysis of seminal fluid from men exhibiting oxidative stress.Reproductive biology and endocrinology : RB&E · 2013Article
- Mechanistic insights into mode of action of novel natural cathepsin L inhibitors.BMC genomics · 2013Article
- Matrix metalloproteinases in cytotoxic lymphocytes impact on tumour infiltration and immunomodulation.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2011Article
- Proteomic analysis of human skin treated with larval schistosome peptidases reveals distinct invasion strategies among species of blood flukes.PLoS neglected tropical diseases · 2011Article
- Cathepsin B trafficking in thyroid carcinoma cells.Thyroid research · 2011Article
- Nuclear cysteine cathepsin variants in thyroid carcinoma cells.Biological chemistry · 2010Article
- Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy.Biochimica et biophysica acta · 2008Review
- Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.World journal of gastroenterology · 2005Article
- Brain metastases in melanoma: roles of neurotrophins.Neuro-oncology · 2004Review
- Cathepsin B in the rat eye.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2003Article
- Brain-metastatic melanoma: a neurotrophic perspective.Pathology oncology research : POR · 2003Review
- A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells.Oncogene · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cysteine proteinases are a subclass of endopeptidases which require activation by thiol reagents. A tumor cysteine proteinase which appears to be related to lysosomal cathepsin B has been implicated in the ability of tumor cells to invade the extracellular matrix and to metastasize to secondary sites. Lysosomal cathepsin B can degrade such components of the extracellular matrix as collagen, fibronectin and proteoglycans. Activity of this cathepsin B-like cysteine proteinase (CB) has been correlated with tumor malignancy in a number of tumor lines yet not in all tumor lines studied. CB activity in tumors seems to be associated with the viable tumor cells, probably with the plasma membrane of these tumor cells. CB activity has been measured in the sera, urine, ascites fluid and pancreatic fluid of tumor-bearing patients. CB is released from tumor explants and tumor cells in vitro as well as from normal subcutaneous tissue exposed to tumor-conditioned medium. Cathepsin B from normal tissues is rapidly inactivated above pH 7.0. Therefore, CB in tumor cell membranes or released from tumor cells (or from host cells in response to tumor cells) may not possess proteolytic activity at neutral pH and thus may not facilitate tumor cell invasion. However, CB exhibits enhanced stability at neutral or slightly alkaline pH's. There is not yet definitive proof that CB plays a role in tumor invasion and metastasis. There is, however, an increasing body of correlative evidence relating CB activity and tumor malignancy. This correlative evidence plus preliminary evidence that tumor CB can degrade components of the extracellular matrix in vitro suggests that CB may be one proteinase active in a proteolytic cascade resulting in tumor invasion and metastasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.